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Spectroscopic and Structural Investigation of the Confinement of d and l Dimethyl Tartrate in Lecithin Reverse Micelles

Abbate, Sergio ; Castiglione, Franca ; Lebon, France ; Longhi, Giovanna ; Longo, Alessandro ; Mele, Andrea ; Panzeri, Walter ; Ruggirello, Angela ; Liveri, Vincenzo Turco

The journal of physical chemistry. B, 2009-03, Vol.113 (10), p.3024-3033 [Periódico revisado por pares]

United States: American Chemical Society

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  • Título:
    Spectroscopic and Structural Investigation of the Confinement of d and l Dimethyl Tartrate in Lecithin Reverse Micelles
  • Autor: Abbate, Sergio ; Castiglione, Franca ; Lebon, France ; Longhi, Giovanna ; Longo, Alessandro ; Mele, Andrea ; Panzeri, Walter ; Ruggirello, Angela ; Liveri, Vincenzo Turco
  • Assuntos: B: Surfactants, Membranes ; Chemistry, Physical - methods ; Dose-Response Relationship, Drug ; Elasticity ; Lecithins - chemistry ; Micelles ; Models, Chemical ; Models, Statistical ; Phosphatidylcholines - chemistry ; Polyethylene Glycols - chemistry ; Rheology - methods ; Spectrophotometry - methods ; Tartrates - chemistry ; Temperature ; Viscosity
  • É parte de: The journal of physical chemistry. B, 2009-03, Vol.113 (10), p.3024-3033
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: The confinement of d and l dimethyl tartrate in lecithin reverse micelles dispersed in cyclohexane has been investigated by FT-IR, polarimetry, electronic and vibrational circular dichroism (ECD and VCD), 1H NMR, and small-angle X-ray scattering (SAXS). Measurements have been performed at room temperature as a function of the solubilizate-to-surfactant molar ratio (R) at fixed lecithin concentration. The analysis of experimental data indicates that the dimethyl tartrate molecules are solubilized within reverse micelles in proximity to the surfactant head groups in the same way for the d and l forms. The encapsulation of dimethyl tatrate within lecithin reverse micelles involves changes in its H-bonds, from what is observed in the pure solid or in CCl4 solutions; this is a consequence of the establishment of specific solute-surfactant headgroup interactions and of confinement effects. In the 0 ≤ R ≤ 1.7 range, SAXS profiles of dimethyl tartrate/lecithin/cyclohexane micellar solutions are well-described by a model of interacting polydisperse spherical micellar cores whose mean radius does not change appreciably with R (i.e., it changes from about 18 to 20 Å). 1H NMR diffusion measurements of both dimethyl tartrates and lecithin were rationalized in terms of collective translational motions of the entire micellar aggregate and of their molecular diffusion among clusters of reverse micelles. The association of optically active lecithin with d and l dimethyl tartrate leads to the formation of self-organized supramolecular aggregates whose interesting chiroptical features are evidenced by polarimetry and CD.
  • Editor: United States: American Chemical Society
  • Idioma: Inglês
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