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Expression of Interleukin-10 in Advanced Human Atherosclerotic Plaques: Relation to Inducible Nitric Oxide Synthase Expression and Cell Death

Mallat, Ziad ; Heymes, Christophe ; Ohan, Jeanny ; Faggin, Elisabetta ; Leseche, Guy ; Tedgui, Alain

Arteriosclerosis, thrombosis, and vascular biology, 1999-03, Vol.19 (3), p.611-616 [Periódico revisado por pares]

Philadelphia, PA: American Heart Association, Inc

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Título:
Expression of Interleukin-10 in Advanced Human Atherosclerotic Plaques: Relation to Inducible Nitric Oxide Synthase Expression and Cell Death
Autor: Mallat, Ziad ; Heymes, Christophe ; Ohan, Jeanny ; Faggin, Elisabetta ; Leseche, Guy ; Tedgui, Alain
Assuntos: Aorta, Abdominal - chemistry ; Aorta, Abdominal - cytology ; Aorta, Abdominal - enzymology ; Aortic Diseases - immunology ; Aortic Diseases - metabolism ; Aortic Diseases - pathology ; Apoptosis - immunology ; Arteriosclerosis - immunology ; Arteriosclerosis - metabolism ; Arteriosclerosis - pathology ; Arteritis - immunology ; Arteritis - metabolism ; Arteritis - pathology ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Blotting, Western ; Cardiology. Vascular system ; Carotid Arteries - chemistry ; Carotid Arteries - cytology ; Carotid Arteries - enzymology ; Carotid Artery Diseases - immunology ; Carotid Artery Diseases - metabolism ; Carotid Artery Diseases - pathology ; Gene Expression Regulation, Enzymologic - immunology ; Humans ; In Situ Nick-End Labeling ; Interleukin-10 - analysis ; Interleukin-10 - genetics ; Medical sciences ; Nitric Oxide Synthase - analysis ; Nitric Oxide Synthase - genetics ; Nitric Oxide Synthase Type II ; RNA, Messenger - analysis
É parte de: Arteriosclerosis, thrombosis, and vascular biology, 1999-03, Vol.19 (3), p.611-616
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Inflammation is a major feature of human atherosclerosis and is central to development and progression of the disease. A variety of proinflammatory cytokines are expressed in the atherosclerotic plaque and may modulate extracellular matrix remodeling, cell proliferation, and cell death. Little is known, however, about the expression and potential role of anti-inflammatory cytokines in human atherosclerosis. Interleukin-10 (IL-10) is a major anti-inflammatory cytokine whose expression and potential effects in advanced human atherosclerotic plaques have not been evaluated. We studied 21 advanced human atherosclerotic plaques. IL-10 expression was analyzed by use of reverse transcription-polymerase chain reaction and immunohistochemical techniques. Inducible nitric oxide synthase expression was assessed by using immunohistochemistry, and cell death was determined by use of the TUNEL method. Reverse transcription-polymerase chain reaction identified IL-10 mRNA in 12 of 17 atherosclerotic plaques. Immunohistochemical staining of serial sections and double staining identified immunoreactive IL-10 mainly in macrophages, as well as in smooth muscle cells. Consistent with its anti-inflammatory properties, high levels of IL-10 expression were associated with significant decrease in inducible nitric oxide synthase expression (P<0.0001) and cell death (P<0.0001). Hence, IL-10, a potent anti-inflammatory cytokine, is expressed in a substantial number of advanced human atherosclerotic plaques and might contribute to the modulation of the local inflammatory response and protect from excessive cell death in the plaque. (Arterioscler Thromb Vasc Biol. 1999;19:611-616.)
Editor: Philadelphia, PA: American Heart Association, Inc
Idioma: Inglês

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