Idioma:

Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis

Musa, J ; Orth, M F ; Dallmayer, M ; Baldauf, M ; Pardo, C ; Rotblat, B ; Kirchner, T ; Leprivier, G ; Grünewald, T G P

Oncogene, 2016-09, Vol.35 (36), p.4675-4688 [Periódico revisado por pares]

England: Nature Publishing Group

Texto completo disponível

Citações Citado por

Enviar para

Título:
Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis
Autor: Musa, J ; Orth, M F ; Dallmayer, M ; Baldauf, M ; Pardo, C ; Rotblat, B ; Kirchner, T ; Leprivier, G ; Grünewald, T G P
Assuntos: Adaptor Proteins, Signal Transducing - genetics ; Binding proteins ; Binding sites ; Cancer ; Carcinogenesis ; Carcinogenesis - genetics ; Cell Proliferation - genetics ; Cell viability ; Eukaryotes ; Eukaryotic Initiation Factor-4E - genetics ; Gene Expression Regulation, Neoplastic ; Genetic aspects ; Genotoxicity ; Humans ; Identification and classification ; Initiation factor eIF-4E ; Metabolism ; Neoplasms - genetics ; Neoplasms - pathology ; Phosphoproteins - genetics ; Phosphorylation ; Properties ; Protein Binding ; Protein Biosynthesis ; Protein synthesis ; Proteins ; Ribonucleic acid ; RNA ; RNA, Messenger - genetics ; Signal Transduction ; Transcription factors ; Tumor microenvironment ; Tumor suppressor genes ; Tumorigenesis
É parte de: Oncogene, 2016-09, Vol.35 (36), p.4675-4688
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
ObjectType-Review-1
ObjectType-Article-1
ObjectType-Feature-2
content type line 23
Descrição: Protein synthesis activity is abnormally enhanced in cancer cells to support their uncontrolled growth. However, this process needs to be tightly restricted under metabolic stress-a condition often found within the tumor microenvironment-to preserve cell viability. mTORC1 is critical to link protein synthesis activity to nutrient and oxygen levels, in part by controlling the 4E-BP1-eIF4E axis. Whereas mTORC1 and eIF4E are known pro-tumorigenic factors, whose expression or activity is increased in numerous cancers, the role of 4E-BP1 in cancer is not yet definitive. On the one hand, 4E-BP1 has tumor suppressor activity by inhibiting eIF4E and, thus, blocking mRNA translation and proliferation. This is corroborated by elevated levels of phosphorylated and hence inactive 4E-BP1, which are detected in various cancers. On the other hand, 4E-BP1 has pro-tumorigenic functions as it promotes tumor adaptation to metabolic and genotoxic stress by selectively enhancing or preventing the translation of specific transcripts. Here we describe the molecular and cellular functions of 4E-BP1 and highlight the distinct roles of 4E-BP1 in cancer depending on the microenvironmental context of the tumor.
Editor: England: Nature Publishing Group
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis

Musa, J ; Orth, M F ; Dallmayer, M ; Baldauf, M ; Pardo, C ; Rotblat, B ; Kirchner, T ; Leprivier, G ; Grünewald, T G P

England: Nature Publishing Group

Buscando em bases de dados remotas. Favor aguardar.