Idioma:

Hydrolase-like catalysis and structural resolution of natural products by a metal-organic framework

Mon, Marta ; Bruno, Rosaria ; Sanz-Navarro, Sergio ; Negro, Cristina ; Ferrando-Soria, Jesús ; Bartella, Lucia ; Di Donna, Leonardo ; Prejanò, Mario ; Marino, Tiziana ; Leyva-Pérez, Antonio ; Armentano, Donatella ; Pardo, Emilio

Nature communications, 2020-06, Vol.11 (1), p.3080-3080, Article 3080 [Periódico revisado por pares]

England: Nature Publishing Group

Texto completo disponível

Citações Citado por

Enviar para

Título:
Hydrolase-like catalysis and structural resolution of natural products by a metal-organic framework
Autor: Mon, Marta ; Bruno, Rosaria ; Sanz-Navarro, Sergio ; Negro, Cristina ; Ferrando-Soria, Jesús ; Bartella, Lucia ; Di Donna, Leonardo ; Prejanò, Mario ; Marino, Tiziana ; Leyva-Pérez, Antonio ; Armentano, Donatella ; Pardo, Emilio
Assuntos: Absolute configuration ; Adsorption ; Alcohols - chemistry ; Amino acids ; Biological Products - chemistry ; Biomimetics ; Catalysis ; Catalysts ; Catalytic activity ; Crystal structure ; Crystallography ; Crystallography, X-Ray ; Glycolysis ; Hydrolase ; Hydrolases - chemistry ; Hydrolysis ; Kinetics ; Metal-organic frameworks ; Metal-Organic Frameworks - chemistry ; Metals ; Molecular Conformation ; Molecular Structure ; Natural products ; Porosity ; Protons ; Structure-Activity Relationship ; X-Ray Diffraction
É parte de: Nature communications, 2020-06, Vol.11 (1), p.3080-3080, Article 3080
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The exact chemical structure of non-crystallising natural products is still one of the main challenges in Natural Sciences. Despite tremendous advances in total synthesis, the absolute structural determination of a myriad of natural products with very sensitive chemical functionalities remains undone. Here, we show that a metal-organic framework (MOF) with alcohol-containing arms and adsorbed water, enables selective hydrolysis of glycosyl bonds, supramolecular order with the so-formed chiral fragments and absolute determination of the organic structure by single-crystal X-ray crystallography in a single operation. This combined strategy based on a biomimetic, cheap, robust and multigram available solid catalyst opens the door to determine the absolute configuration of ketal compounds regardless degradation sensitiveness, and also to design extremely-mild metal-free solid-catalysed processes without formal acid protons.
Editor: England: Nature Publishing Group
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Hydrolase-like catalysis and structural resolution of natural products by a metal-organic framework

Mon, Marta ; Bruno, Rosaria ; Sanz-Navarro, Sergio ; Negro, Cristina ; Ferrando-Soria, Jesús ; Bartella, Lucia ; Di Donna, Leonardo ; Prejanò, Mario ; Marino, Tiziana ; Leyva-Pérez, Antonio ; Armentano, Donatella ; Pardo, Emilio

England: Nature Publishing Group

Buscando em bases de dados remotas. Favor aguardar.