skip to main content
Idioma:
Primo Search
Clear Search Box
Search in: Busca Geral
Busca Avançada
Busca por Índices

Clinical management of Plasmodium knowlesi malaria

Barber, Bridget E ; Grigg, Matthew J ; Cooper, Daniel J ; van Schalkwyk, Donelly A ; William, Timothy ; Rajahram, Giri S ; Anstey, Nicholas M

Advances in parasitology, 2021, Vol.113, p.45-76 [Periódico revisado por pares]

Texto completo disponível

Citações Citado por
  • Título:
    Clinical management of Plasmodium knowlesi malaria
  • Autor: Barber, Bridget E ; Grigg, Matthew J ; Cooper, Daniel J ; van Schalkwyk, Donelly A ; William, Timothy ; Rajahram, Giri S ; Anstey, Nicholas M
  • É parte de: Advances in parasitology, 2021, Vol.113, p.45-76
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-2
  • Descrição: The zoonotic parasite Plasmodium knowlesi has emerged as an important cause of human malaria in parts of Southeast Asia. The parasite is indistinguishable by microscopy from the more benign P. malariae , but can result in high parasitaemias with multiorgan failure, and deaths have been reported. Recognition of severe knowlesi malaria, and prompt initiation of effective therapy is therefore essential to prevent adverse outcomes. Here we review all studies reporting treatment of uncomplicated and severe knowlesi malaria. We report that although chloroquine is effective for the treatment of uncomplicated knowlesi malaria, artemisinin combination treatment is associated with faster parasite clearance times and lower rates of anaemia during follow-up, and should be considered the treatment of choice, particularly given the risk of administering chloroquine to drug-resistant P. vivax or P. falciparum misdiagnosed as P. knowlesi malaria in co-endemic areas. For severe knowlesi malaria, intravenous artesunate has been shown to be highly effective and associated with reduced case-fatality rates, and should be commenced without delay. Regular paracetamol may also be considered for patients with severe knowlesi malaria or for those with acute kidney injury, to attenuate the renal damage resulting from haemolysis-induced lipid peroxidation.
  • Idioma: Inglês
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.