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Modulation of mitochondrial bioenergetics as a therapeutic strategy in Alzheimer's disease

Onyango, Isaac

Neural regeneration research, 2018-01, Vol.13 (1), p.19-25 [Periódico revisado por pares]

India: Wolters Kluwer India Pvt. Ltd

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Título:
Modulation of mitochondrial bioenergetics as a therapeutic strategy in Alzheimer's disease
Autor: Onyango, Isaac
Assuntos: Alzheimer's disease ; Alzheimer′s disease; mitochondria; bioenergetics; mitochondrial DNA; neuroinflammation; mitohormesis; caloric restriction; hypometabolism; mitophagy; mitochondrial biogenesis; recombinant-human mitochondrial transcription factor A; antioxidants; proteasome; mitochondrial transcription activator-like effector nucleases; clustered regularly interspaced short palindromic repeats/associated protein 9 (CRISPR/ Cas9); caloric restriction; stem cells ; Analysis ; Care and treatment ; Development and progression ; Energy metabolism ; Health aspects ; Invited Review ; Mitochondria ; Mitochondrial DNA ; Mutation ; Neurodegeneration ; Stem cells
É parte de: Neural regeneration research, 2018-01, Vol.13 (1), p.19-25
Notas: ObjectType-Article-2
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Author contributions: IGO wrote the manuscript and made the figure.
Descrição: Alzheimer's disease (AD) is an increasingly pressing worldwide public-health, social, political and economic concern. Despite significant investment in multiple traditional therapeutic strategies that have achieved success in preclinical models addressing the pathological hallmarks of the disease, these efforts have not translated into any effective disease-modifying therapies. This could be because interventions are being tested too late in the disease process. While existing therapies provide symptomatic and clinical benefit, they do not fully address the molecular abnormalities that occur in AD neurons. The pathophysiology of AD is complex; mitochondrial bioenergetic deficits and brain hypometabolism coupled with increased mitochondrial oxidative stress are antecedent and potentially play a causal role in the disease pathogenesis. Dysfunctional mitochondria accumulate from the combination of impaired mitophagy, which can also induce injurious inflammatory responses, and inadequate neuronal mitochondrial biogenesis. Altering the metabolic capacity of the brain by modulating/potentiating its mitochondrial bioenergetics may be a strategy for disease prevention and treatment. We present insights into the mechanisms of mitochondrial dysfunction in AD brain as well as an overview of emerging treatments with the potential to prevent, delay or reverse the neurodegenerative process by targeting mitochondria.
Editor: India: Wolters Kluwer India Pvt. Ltd
Idioma: Inglês

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Modulation of mitochondrial bioenergetics as a therapeutic strategy in Alzheimer's disease

Onyango, Isaac

India: Wolters Kluwer India Pvt. Ltd

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