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Molecular characteristics of HIV type 1 circulating in Sao Paulo, Brazil

BRIGIDO, Luis F. M ; FRANCO, Heitor M ; CUSTODIO, Renata M ; OLIVEIRA, Carmen A. F ; FERREIRA, Joao Leandro P ; EIRA, Margareth ; BERGEL, Fernando ; ARAUJO, Fabio ; CARVALHEIRO, Jose R ; RODRIGUES, Rosangela

AIDS research and human retroviruses, 2005-07, Vol.21 (7), p.673-682 [Periódico revisado por pares]

Larchmont, NY: Liebert

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Título:
Molecular characteristics of HIV type 1 circulating in Sao Paulo, Brazil
Autor: BRIGIDO, Luis F. M ; FRANCO, Heitor M ; CUSTODIO, Renata M ; OLIVEIRA, Carmen A. F ; FERREIRA, Joao Leandro P ; EIRA, Margareth ; BERGEL, Fernando ; ARAUJO, Fabio ; CARVALHEIRO, Jose R ; RODRIGUES, Rosangela
Assuntos: AIDS/HIV ; Amino Acid Sequence ; Base Sequence ; Biological and medical sciences ; Brazil ; DNA Primers ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Products, env - genetics ; Gene Products, gag - genetics ; Gene Products, pol - genetics ; HIV Infections - virology ; HIV-1 - classification ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Microbiology ; Miscellaneous ; Molecular Sequence Data ; Phylogeny ; Sequence Homology, Amino Acid ; Viral diseases ; Virology
É parte de: AIDS research and human retroviruses, 2005-07, Vol.21 (7), p.673-682
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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Descrição: Partial sequences of HIV-1 polymerase from 185 patients, 141 ARV experienced and 44 naive, of gag (p24) and env (C2V3) from a subset of naive cases were evaluated in São Paulo, Brazil. Antiretroviral resistance mutations were detected in 4% of 26 recently (<2 years) infected patients. Polymorphisms at the protease gene were common both in contemporary and pre-HAART era isolates, some significantly associated with the viral clade. HIV-1 clade B was preponderant, in 79%, with 11% clade F and one case of HIV-1 C. Recently infected women had a significantly higher proportion of non-B clade HIV-1. A mosaic pol was observed in 9%, all B/F except for one G mosaic. A CRF-12-BF structure, observed in 20% of B/F pol mosaics, provides evidence for an epidemic relationship in the major South American metropolitan areas.
Editor: Larchmont, NY: Liebert
Idioma: Inglês

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Molecular characteristics of HIV type 1 circulating in Sao Paulo, Brazil

BRIGIDO, Luis F. M ; FRANCO, Heitor M ; CUSTODIO, Renata M ; OLIVEIRA, Carmen A. F ; FERREIRA, Joao Leandro P ; EIRA, Margareth ; BERGEL, Fernando ; ARAUJO, Fabio ; CARVALHEIRO, Jose R ; RODRIGUES, Rosangela

Larchmont, NY: Liebert

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