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Evolutionary divergence of TLR9 through ancestral sequence reconstruction

Ghosh, Manisha ; Basak, Surajit ; Dutta, Shanta

Immunogenetics (New York), 2024-06, Vol.76 (3), p.203-211 [Periódico revisado por pares]

Berlin/Heidelberg: Springer Berlin Heidelberg

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Título:
Evolutionary divergence of TLR9 through ancestral sequence reconstruction
Autor: Ghosh, Manisha ; Basak, Surajit ; Dutta, Shanta
Assuntos: Allergology ; Amino Acid Sequence ; Amino acids ; Animals ; Base Composition ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Cholera ; Divergence ; Evolution ; Evolution, Molecular ; Evolutionary genetics ; Gene Function ; Genes ; Genetic Variation ; Genomes ; Human Genetics ; Humans ; Hydrophobicity ; Immune response ; Immune system ; Immunology ; Innate immunity ; Mammals ; Molecular evolution ; Mutation ; Nucleotide sequence ; Original Article ; Pathogens ; Pattern recognition ; Pattern recognition receptors ; Phylogenetics ; Phylogeny ; Proteins ; Reconstruction ; Statistical analysis ; TLR9 protein ; Toll-Like Receptor 9 - genetics ; Toll-like receptors ; Vaccines
É parte de: Immunogenetics (New York), 2024-06, Vol.76 (3), p.203-211
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The transmembrane pattern recognition receptor, Toll-like receptor (TLR), are best known for their roles in innate immunity via recognition of pathogen and initiation of signaling response. Mammalian TLRs recognize molecular patterns associated with pathogens and initiate innate immune response. We have studied the evolutionary diversity of mammalian TLR genes for differences in immunological response. Reconstruction of ancestral sequences is a key aspect of the molecular evolution of TLR to track changes across the TLR genes. The comprehensive analysis of mammalian TLRs revealed a distinct pattern of evolution of TLR9. Various sequence-based features such as amino acid usage, hydrophobicity, GC content, and evolutionary constraints are found to influence the divergence of TLR9 from other TLRs. Ancestral sequence reconstruction analysis also revealed that the gradual evolution of TLR genes in several ancestral lineages leads to the distinct pattern of TLR9. It demonstrates evolutionary divergence with the progressive accumulation of mutations results in the distinct pattern of TLR9.
Editor: Berlin/Heidelberg: Springer Berlin Heidelberg
Idioma: Inglês

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Evolutionary divergence of TLR9 through ancestral sequence reconstruction

Ghosh, Manisha ; Basak, Surajit ; Dutta, Shanta

Berlin/Heidelberg: Springer Berlin Heidelberg

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