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Human papillomavirus as a driver of head and neck cancers

Sabatini, Maria Elisa ; Chiocca, Susanna

British journal of cancer, 2020-02, Vol.122 (3), p.306-314 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Human papillomavirus as a driver of head and neck cancers
Autor: Sabatini, Maria Elisa ; Chiocca, Susanna
Assuntos: Cervical cancer ; DNA, Viral - analysis ; Epidemiology ; Epithelium ; Ethnic Groups ; Head & neck cancer ; Head and neck ; Head and Neck Neoplasms - epidemiology ; Head and Neck Neoplasms - ethnology ; Head and Neck Neoplasms - virology ; Health risk assessment ; Human papillomavirus ; Human papillomavirus 16 - genetics ; Human papillomavirus 16 - pathogenicity ; Human papillomavirus 18 - genetics ; Human papillomavirus 18 - pathogenicity ; Humans ; In Situ Hybridization ; Oropharynx ; Papillomaviridae - genetics ; Papillomaviridae - pathogenicity ; Papillomavirus Infections - diagnosis ; Papillomavirus Infections - epidemiology ; Papillomavirus Infections - ethnology ; Papillomavirus Infections - virology ; Prevalence ; Prognosis ; Reverse Transcriptase Polymerase Chain Reaction ; Review ; Risk Factors ; RNA, Viral - analysis ; Sex Factors ; Squamous Cell Carcinoma of Head and Neck - epidemiology ; Squamous Cell Carcinoma of Head and Neck - ethnology ; Squamous Cell Carcinoma of Head and Neck - virology ; Subpopulations
É parte de: British journal of cancer, 2020-02, Vol.122 (3), p.306-314
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: The human papillomavirus (HPV) family includes more than 170 different types of virus that infect stratified epithelium. High-risk HPV is well established as the primary cause of cervical cancer, but in recent years, a clear role for this virus in other malignancies is also emerging. Indeed, HPV plays a pathogenic role in a subset of head and neck cancers-mostly cancers of the oropharynx-with distinct epidemiological, clinical and molecular characteristics compared with head and neck cancers not caused by HPV. This review summarises our current understanding of HPV in these cancers, specifically detailing HPV infection in head and neck cancers within different racial/ethnic subpopulations, and the differences in various aspects of these diseases between women and men. Finally, we provide an outlook for this disease, in terms of clinical management, and consider the issues of 'diagnostic biomarkers' and targeted therapies.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Human papillomavirus as a driver of head and neck cancers

Sabatini, Maria Elisa ; Chiocca, Susanna

England: Nature Publishing Group

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