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The molecular characteristics of colorectal cancer: Implications for diagnosis and therapy
Nguyen, Ha Thi ; Duong, Hong-Quan
Oncology letters, 2018-07, Vol.16 (1), p.9-18
Greece: Spandidos Publications
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Título:
The molecular characteristics of colorectal cancer: Implications for diagnosis and therapy
Autor:
Nguyen, Ha Thi
;
Duong, Hong-Quan
Assuntos:
Biomarkers
;
Cancer therapies
;
Care and treatment
;
Cell cycle
;
Cell growth
;
Chemotherapy
;
Chromosomes
;
Colorectal cancer
;
Deoxyribonucleic acid
;
Development and progression
;
DNA
;
Epigenetics
;
Gene expression
;
Genetic aspects
;
Health aspects
;
Immunotherapy
;
Innovations
;
Kinases
;
Medical diagnosis
;
Medical prognosis
;
Metastasis
;
Microsatellites (Genetics)
;
Molecular targeted therapy
;
Mutation
;
Oncology
;
Review
;
Tumors
É parte de:
Oncology letters, 2018-07, Vol.16 (1), p.9-18
Notas:
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição:
Colorectal cancer (CRC) results from the progressive accumulation of multiple genetic and epigenetic aberrations within cells. The progression from colorectal adenoma to carcinoma is caused by three major pathways: Microsatellite instability, chromosomal instability and CpG island methylator phenotype. A growing body of scientific evidences suggests that CRC is a heterogeneous disease, and genetic characteristics of the tumors determine their prognostic outcome and response to targeted therapies. Early diagnosis and effective targeted therapies based on a current knowledge of the molecular characteristics of CRC are essential to the successful treatment of CRC. Therefore, the present review summarized the current understanding of the molecular characteristics of CRC, and discussed its implications for diagnosis and targeted therapy.
Editor:
Greece: Spandidos Publications
Idioma:
Inglês
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