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MOG encephalomyelitis: international recommendations on diagnosis and antibody testing

Jarius, S ; Paul, F ; Aktas, O ; Asgari, N ; Dale, R C ; de Seze, J ; Franciotta, D ; Fujihara, K ; Jacob, A ; Kim, H J ; Kleiter, I ; Kümpfel, T ; Levy, M ; Palace, J ; Ruprecht, K ; Saiz, A ; Trebst, C ; Weinshenker, B G ; Wildemann, B

Nervenarzt, 2018-12, Vol.89 (12), p.1388 [Periódico revisado por pares]

Germany

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Título:
MOG encephalomyelitis: international recommendations on diagnosis and antibody testing
Autor: Jarius, S ; Paul, F ; Aktas, O ; Asgari, N ; Dale, R C ; de Seze, J ; Franciotta, D ; Fujihara, K ; Jacob, A ; Kim, H J ; Kleiter, I ; Kümpfel, T ; Levy, M ; Palace, J ; Ruprecht, K ; Saiz, A ; Trebst, C ; Weinshenker, B G ; Wildemann, B
Assuntos: Aquaporin 4 ; Autoantibodies - blood ; Encephalomyelitis - blood ; Encephalomyelitis - diagnosis ; Expert Testimony ; Humans ; Myelin-Oligodendrocyte Glycoprotein - immunology ; Neuromyelitis Optica - blood ; Neuromyelitis Optica - diagnosis ; Optic Neuritis
É parte de: Nervenarzt, 2018-12, Vol.89 (12), p.1388
Descrição: Over the past few years, new-generation cell-based assays have demonstrated a robust association of autoantibodies to full-length human myelin oligodendrocyte glycoprotein (MOG-IgG) with (mostly recurrent) optic neuritis, myelitis and brainstem encephalitis, as well as with acute disseminated encephalomyelitis (ADEM)-like presentations. Most experts now consider MOG-IgG-associated encephalomyelitis (MOG-EM) a disease entity in its own right, immunopathogenetically distinct from both classic multiple sclerosis (MS) and aquaporin-4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorders (NMOSD). Owing to a substantial overlap in clinicoradiological presentation, MOG-EM was often unwittingly misdiagnosed as MS in the past. Accordingly, increasing numbers of patients with suspected or established MS are currently being tested for MOG-IgG. However, screening of large unselected cohorts for rare biomarkers can significantly reduce the positive predictive value of a test. To lessen the hazard of overdiagnosing MOG-EM, which may lead to inappropriate treatment, more selective criteria for MOG-IgG testing are urgently needed. In this paper, we propose indications for MOG-IgG testing based on expert consensus. In addition, we give a list of conditions atypical for MOG-EM ("red flags") that should prompt physicians to challenge a positive MOG-IgG test result. Finally, we provide recommendations regarding assay methodology, specimen sampling and data interpretation, and propose for the first time diagnostic criteria for MOG-EM.
Editor: Germany
Idioma: Alemão

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MOG encephalomyelitis: international recommendations on diagnosis and antibody testing

Jarius, S ; Paul, F ; Aktas, O ; Asgari, N ; Dale, R C ; de Seze, J ; Franciotta, D ; Fujihara, K ; Jacob, A ; Kim, H J ; Kleiter, I ; Kümpfel, T ; Levy, M ; Palace, J ; Ruprecht, K ; Saiz, A ; Trebst, C ; Weinshenker, B G ; Wildemann, B

Germany

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