Idioma:

The effect on clinical outcomes when targeting spinal manipulation at stiffness or pain sensitivity: a randomized trial

Nim, Casper Glissmann ; Kawchuk, Gregory Neil ; Schiøttz-Christensen, Berit ; O'Neill, Søren

Scientific reports, 2020-09, Vol.10 (1), p.14615-14615, Article 14615 [Periódico revisado por pares]

England: Nature Publishing Group

Texto completo disponível

Citações Citado por

Enviar para

Título:
The effect on clinical outcomes when targeting spinal manipulation at stiffness or pain sensitivity: a randomized trial
Autor: Nim, Casper Glissmann ; Kawchuk, Gregory Neil ; Schiøttz-Christensen, Berit ; O'Neill, Søren
Assuntos: Adenine ; Adult ; Apoptosis ; Bcl-2 protein ; Biomechanical Phenomena - physiology ; c-Jun protein ; Caspase ; Caspase-3 ; Female ; Gentamicin ; Glutathione peroxidase ; Humans ; Hydrogen sulfide ; Interleukin 10 ; Kinases ; Low Back Pain - physiopathology ; Low Back Pain - therapy ; Lumbosacral Region - physiopathology ; Male ; Malondialdehyde ; Manipulation, Spinal ; MAP kinase ; Middle Aged ; Monocyte chemoattractant protein ; Monocyte chemoattractant protein 1 ; NF-κB protein ; Pain Measurement ; Pain Threshold - physiology ; Phosphorylation ; Protein kinase ; Proteins ; Public health ; Renal failure ; Signal transduction ; Superoxide dismutase ; Transcription factors ; Treatment Outcome
É parte de: Scientific reports, 2020-09, Vol.10 (1), p.14615-14615, Article 14615
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
ObjectType-Feature-3
content type line 23
Descrição: The mechanisms underlying pain relief following spinal manipulative therapy (SMT) are not understood fully although biomechanical and neurophysiological processes have been proposed. As such, we designed this randomized trial to elucidate the contributions of biomechanical and neurophysiological processes. A total of 132 participants with low back pain were randomly assigned to receive SMT at either the lumbar segment measured as the stiffest or the segment measured as having the lowest pain threshold. The primary outcome was patient reported low back pain intensity following treatment. Secondary outcomes were biomechanical stiffness and neurophysiological pressure pain threshold. All outcomes were measured at baseline, after the fourth and final session and at 2-weeks follow-up. Data were analyzed using linear mixed models, and demonstrated that the SMT application site did not influence patient reported low back pain intensity or stiffness. However, a large and significant difference in pressure pain threshold was observed between groups. This study provides support that SMT impacts neurophysiological parameters through a segment-dependent neurological reflex pathway, although this do not seem to be a proxy for improvement. This study was limited by the assumption that the applied treatment was sufficient to impact the primary outcome.
Editor: England: Nature Publishing Group
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 4 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

The effect on clinical outcomes when targeting spinal manipulation at stiffness or pain sensitivity: a randomized trial

Nim, Casper Glissmann ; Kawchuk, Gregory Neil ; Schiøttz-Christensen, Berit ; O'Neill, Søren

England: Nature Publishing Group

Buscando em bases de dados remotas. Favor aguardar.