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Reducing the incidence of surgical site infection after ventral hernia repair: Outcomes from the RINSE randomized control trial

Warren, Jeremy A ; Lucas, Claiborne ; Beffa, Lucas R ; Petro, Clayton C ; Prabhu, Ajita S ; Krpata, David M ; Rosen, Michael J ; Orenstein, Sean B ; Nikolian, Vahagn C ; Pauli, Eric M ; Horne, Charlotte M ; LaBelle, Molly ; Phillips, Sharon ; Poulose, Benjamin K ; Carbonell, Alfredo M

The American journal of surgery, 2024-06, Vol.232, p.68-74 [Periódico revisado por pares]

United States: Elsevier Limited

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Título:
Reducing the incidence of surgical site infection after ventral hernia repair: Outcomes from the RINSE randomized control trial
Autor: Warren, Jeremy A ; Lucas, Claiborne ; Beffa, Lucas R ; Petro, Clayton C ; Prabhu, Ajita S ; Krpata, David M ; Rosen, Michael J ; Orenstein, Sean B ; Nikolian, Vahagn C ; Pauli, Eric M ; Horne, Charlotte M ; LaBelle, Molly ; Phillips, Sharon ; Poulose, Benjamin K ; Carbonell, Alfredo M
Assuntos: Abdomen ; Adult ; Aged ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Chronic obstructive pulmonary disease ; Clindamycin ; Clindamycin - administration & dosage ; Clindamycin - therapeutic use ; Diabetes ; Female ; Gentamicin ; Gentamicins - administration & dosage ; Gentamicins - therapeutic use ; Hernia ; Hernia, Ventral - surgery ; Hernias ; Herniorrhaphy - adverse effects ; Humans ; Incidence ; Infectious diseases ; Intervention ; Irrigation ; Laparoscopy ; Lavage ; Male ; Middle Aged ; Patients ; Prospective Studies ; Surgeons ; Surgery ; Surgical Mesh ; Surgical site infections ; Surgical Wound Infection - epidemiology ; Surgical Wound Infection - prevention & control ; Therapeutic Irrigation - methods ; Treatment Outcome
É parte de: The American journal of surgery, 2024-06, Vol.232, p.68-74
Notas: ObjectType-Article-1
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Descrição: The clinical and financial impact of surgical site infection after ventral hernia repair is significant. Here we investigate the impact of dual antibiotic irrigation on SSI after VHR. This was a multicenter, prospective randomized control trial of open retromuscular VHR with mesh. Patients were randomized to gentamicin + clindamycin (G + C) (n = 125) vs saline (n = 125) irrigation at time of mesh placement. Primary outcome was 30-day SSI. No significant difference was seen in SSI between control and antibiotic irrigation (9.91 vs 9.09 %; p = 0.836). No differences were seen in secondary outcomes: SSO (11.71 vs 13.64 %; p = 0.667); 90-day SSO (11.1 vs 13.9 %; p = 0.603); 90-day SSI (6.9 vs 3.8 %; p = 0.389); SSIPI (7.21 vs 7.27 %, p = 0.985); SSOPI (3.6 vs 3.64 %; p = 0.990); 30-day readmission (9.91 vs 6.36 %; p = 0.335); reoperation (5.41 vs 0.91 %; p = 0.056). Dual antibiotic irrigation with G + C did not reduce the risk of surgical site infection during open retromuscular ventral hernia repair.
Editor: United States: Elsevier Limited
Idioma: Inglês

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Reducing the incidence of surgical site infection after ventral hernia repair: Outcomes from the RINSE randomized control trial

Warren, Jeremy A ; Lucas, Claiborne ; Beffa, Lucas R ; Petro, Clayton C ; Prabhu, Ajita S ; Krpata, David M ; Rosen, Michael J ; Orenstein, Sean B ; Nikolian, Vahagn C ; Pauli, Eric M ; Horne, Charlotte M ; LaBelle, Molly ; Phillips, Sharon ; Poulose, Benjamin K ; Carbonell, Alfredo M

United States: Elsevier Limited

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