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Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study

Jakszyn, Paula ; Bingham, Sheila ; Pera, Guillem ; Agudo, Antonio ; Luben, Robert ; Welch, Ailsa ; Boeing, Heiner ; del Giudice, Giuseppe ; Palli, Domenico ; Saieva, Calogero ; Krogh, Vittorio ; Sacerdote, Carlotta ; Tumino, Rosario ; Panico, Salvatore ; Berglund, Göran ; Simán, Henrik ; Hallmans, Göran ; Sanchez, María José ; Larrañaga, Nerea ; Barricarte, Aurelio ; Chirlaque, María Dolores ; Quirós, José R. ; Key, Timothy J. ; Allen, Naomi ; Lund, Eiliv ; Carneiro, Fátima ; Linseisen, Jakob ; Nagel, Gabriele ; Overvad, Kim ; Tjonneland, Anne ; Olsen, Anja ; Bueno-de-Mesquita, H. Bas ; Ocké, Marga O. ; Peeters, Petra HM ; Numans, Mattijs E. ; Clavel-Chapelon, Françoise ; Trichopoulou, Antonia ; Fenger, Claus ; Stenling, Roger ; Ferrari, Pietro ; Jenab, Mazda ; Norat, Teresa ; Riboli, Elio ; Gonzalez, Carlos A.

Carcinogenesis (New York), 2006-07, Vol.27 (7), p.1497-1501 [Periódico revisado por pares]

Oxford: Oxford University Press

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Título:
Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study
Autor: Jakszyn, Paula ; Bingham, Sheila ; Pera, Guillem ; Agudo, Antonio ; Luben, Robert ; Welch, Ailsa ; Boeing, Heiner ; del Giudice, Giuseppe ; Palli, Domenico ; Saieva, Calogero ; Krogh, Vittorio ; Sacerdote, Carlotta ; Tumino, Rosario ; Panico, Salvatore ; Berglund, Göran ; Simán, Henrik ; Hallmans, Göran ; Sanchez, María José ; Larrañaga, Nerea ; Barricarte, Aurelio ; Chirlaque, María Dolores ; Quirós, José R. ; Key, Timothy J. ; Allen, Naomi ; Lund, Eiliv ; Carneiro, Fátima ; Linseisen, Jakob ; Nagel, Gabriele ; Overvad, Kim ; Tjonneland, Anne ; Olsen, Anja ; Bueno-de-Mesquita, H. Bas ; Ocké, Marga O. ; Peeters, Petra HM ; Numans, Mattijs E. ; Clavel-Chapelon, Françoise ; Trichopoulou, Antonia ; Fenger, Claus ; Stenling, Roger ; Ferrari, Pietro ; Jenab, Mazda ; Norat, Teresa ; Riboli, Elio ; Gonzalez, Carlos A.
Assuntos: Adenocarcinoma - epidemiology ; Adenocarcinoma - etiology ; Adenocarcinoma/epidemiology/etiology ; Animals ; apparent total NOCs ; Ascorbic Acid - blood ; ATNC ; Biological and medical sciences ; Cancer and Oncology ; Cancer och onkologi ; Carcinogenesis, carcinogens and anticarcinogens ; Case-Control Studies ; Cattle ; Clinical Medicine ; Diet ; Dimethylnitrosamine - metabolism ; endogenous NOC ; ENOC ; EPIC ; Europe ; European Prospective Investigation into Cancer and Nutrition ; Female ; gastric cancer ; Gastroenterology. Liver. Pancreas. Abdomen ; hazard ratio ; Helicobacter Infections - epidemiology ; Helicobacter pylori ; Humans ; Iron ; Klinisk medicin ; Male ; Meat - adverse effects ; Medical and Health Sciences ; Medical sciences ; Medicin och hälsovetenskap ; Middle Aged ; N-nitroso compounds ; NDMA ; Nitrosamines - metabolism ; Nitrosamines - pharmacology ; Nitrosamines/metabolism/pharmacology ; nitrosodimethylamine ; NOCs ; Prospective Studies ; Risk Factors ; Stomach Neoplasms - epidemiology ; Stomach Neoplasms - etiology ; Stomach Neoplasms/epidemiology/etiology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors
É parte de: Carcinogenesis (New York), 2006-07, Vol.27 (7), p.1497-1501
Notas: local:bgl019
istex:46D92BE909E11A0E9BBC81A933055CABD0FBAC28
ark:/67375/HXZ-C25NR0NF-P
To whom correspondence and requests for reprints should be addressed at: Department of Epidemiology, Catalan Institute of Oncology (ICO-IDIBELL), Avenue Gran vía s/n km. 2.7 (08907) L'Hospitalet de Llobregat, Barcelona, Spain. Email: paujak@ico.scs.es
ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: The risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521 457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) formation was estimated using data of the iron content from meat intake and faecal apparent total NOC formation according to previous published studies. Antibodies to Helicobacter pylori and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case–control within the cohort. Exposure to NDMA was <1 μg on average compared with 93 μg on average from ENOC. There was no association between NDMA intake and GC risk (HR, 1.00; 95% CI, 0.7–1.43). ENOC was significantly associated with non-cardia cancer risk (HR, 1.42; 95% CI, 1.14–1.78 for an increase of 40 μg/day) but not with cardia cancer (HR, 0.96; 95% CI, 0.69–1.33). Although the number of not infected cases is low, our data suggest a possible interaction between ENOC and H.pylori infection (P for interaction = 0.09). Moreover, we observed an interaction between plasma vitamin C and ENOC (P < 0.02). ENOC formation may account for our previously reported association between red and processed meat consumption and gastric cancer risk.
Editor: Oxford: Oxford University Press
Idioma: Inglês

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Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study

Oxford: Oxford University Press

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