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Towards a functional understanding of protein N-terminal acetylation

Arnesen, Thomas

PLoS Biology, 2011-05, Vol.9 (5), p.e1001074-e1001074 [Periódico revisado por pares]

United States: Public Library of Science

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  • Título:
    Towards a functional understanding of protein N-terminal acetylation
  • Autor: Arnesen, Thomas
  • Assuntos: Acetylation ; Amino acids ; Biology ; Cellular proteins ; Enzymes ; Genetics ; Hypotheses ; Physiological aspects ; Primer ; Protein Processing, Post-Translational ; Protein Stability ; Proteins ; Proteins - genetics ; Proteins - metabolism ; Secretory Pathway ; Signal Transduction ; Transferases
  • É parte de: PLoS Biology, 2011-05, Vol.9 (5), p.e1001074-e1001074
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Primers provide a concise introduction into an important aspect of biology highlighted by a current PLoS Biology research article.
  • Descrição: Protein N-terminal acetylation is a major modification of eukaryotic proteins. Its functional implications include regulation of protein-protein interactions and targeting to membranes, as demonstrated by studies of a handful of proteins. Fifty years after its discovery, a potential general function of the N-terminal acetyl group carried by thousands of unique proteins remains enigmatic. However, recent functional data suggest roles for N-terminal acetylation as a degradation signal and as a determining factor for preventing protein targeting to the secretory pathway, thus highlighting N-terminal acetylation as a major determinant for the life and death of proteins. These contributions represent new and intriguing hypotheses that will guide the research in the years to come.
  • Editor: United States: Public Library of Science
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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