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The use of genomics, proteomics, and metabolomics in identifying biomarkers of male infertility

Kovac, Jason R., M.D., Ph.D ; Pastuszak, Alexander W., M.D., Ph.D ; Lamb, Dolores J., Ph.D

Fertility and sterility, 2013-03, Vol.99 (4), p.998-1007 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
The use of genomics, proteomics, and metabolomics in identifying biomarkers of male infertility
Autor: Kovac, Jason R., M.D., Ph.D ; Pastuszak, Alexander W., M.D., Ph.D ; Lamb, Dolores J., Ph.D
Assuntos: biomarker ; biomarkers ; Biomarkers - metabolism ; cost effectiveness ; genes ; genomics ; Genomics - methods ; Humans ; Infertility, Male - diagnosis ; Infertility, Male - genetics ; Infertility, Male - metabolism ; Internal Medicine ; Male ; male fertility ; Male infertility ; metabolites ; metabolomics ; Metabolomics - methods ; Obstetrics and Gynecology ; proteins ; proteomics ; Proteomics - methods ; Reproductive Medicine - methods ; semen ; technology
É parte de: Fertility and sterility, 2013-03, Vol.99 (4), p.998-1007
Notas: http://dx.doi.org/10.1016/j.fertnstert.2013.01.111
ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
Descrição: Although male factors account for approximately 50% of all infertility, the mechanisms underlying their origin are unknown. Currently, clinicians rely primarily on semen analyses to predict male reproductive potential and chart treatment success. Even when invasive procedures are performed, the causes of male factor infertility frequently remain elusive. Recently, the advent of new technologies has spurred the search for novel male infertility biomarkers, and the detection of genes, proteins, or metabolites unique to the infertile male holds much promise. The concept that a cost-effective, noninvasive, and accurate set of biomarkers can be identified to diagnose male factor infertility is tantalizing. This review focuses on the various methodologies used in the discovery of novel biomarkers along with their findings. Specific attention is paid to recent advances in the fields of genetics, proteomics, and metabolomics.
Editor: United States: Elsevier Inc
Idioma: Inglês

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The use of genomics, proteomics, and metabolomics in identifying biomarkers of male infertility

Kovac, Jason R., M.D., Ph.D ; Pastuszak, Alexander W., M.D., Ph.D ; Lamb, Dolores J., Ph.D

United States: Elsevier Inc

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