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Proteasome composition in immune cells implies special immune‐cell‐specific immunoproteasome function

Inholz, Katharina ; Anderl, Janet L. ; Klawitter, Moritz ; Goebel, Heike ; Maurits, Elmer ; Kirk, Christopher J. ; Fan, R. Andrea ; Basler, Michael

European journal of immunology, 2024-04, Vol.54 (4), p.e2350613-n/a [Periódico revisado por pares]

Weinheim: Wiley Subscription Services, Inc

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  • Título:
    Proteasome composition in immune cells implies special immune‐cell‐specific immunoproteasome function
  • Autor: Inholz, Katharina ; Anderl, Janet L. ; Klawitter, Moritz ; Goebel, Heike ; Maurits, Elmer ; Kirk, Christopher J. ; Fan, R. Andrea ; Basler, Michael
  • Assuntos: CD11c antigen ; CD19 antigen ; CD1c antigen ; CD4 antigen ; CD49d antigen ; CD56 antigen ; CD8 antigen ; Dendritic cells ; Expression ; Immune cells ; Immunoproteasome ; Inflammation ; Leukocytes (granulocytic) ; Leukocytes (neutrophilic) ; Lymphocytes ; Lymphocytes B ; Lymphocytes T ; Lymphoid tissue ; Natural killer cells ; Peripheral blood ; Proteasome ; Proteasomes
  • É parte de: European journal of immunology, 2024-04, Vol.54 (4), p.e2350613-n/a
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
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  • Descrição: Immunoproteasomes are a special class of proteasomes, which can be induced with IFN‐γ in an inflammatory environment. In recent years, it became evident that certain immune cell types constitutively express high levels of immunoproteasomes. However, information regarding the basal expression of proteolytically active immunoproteasome subunits in different types of immune cells is still rare. Hence, we quantified standard proteasome subunits (β1c, β2c, β5c) and immunoproteasome subunits (LMP2, MECL‐1, LMP7) in the major murine (CD4+ T cells, CD8+ T cells, CD19+ B cells, CD11c+ dendritic cells, CD49d+ natural killer cells, Ly‐6G+ neutrophils) and human immune cell (CD4+ T cells, CD8+ T cells, CD19+ B cells, CD1c+CD141+ myeloid dendritic cells, CD56+ natural killer cells, granulocytes) subsets. The different human immune cell types were isolated from peripheral blood and the murine immune cell subsets from spleen. We found that proteasomes of most immune cell subsets mainly consist of immunoproteasome subunits. Our data will serve as a reference and guideline for immunoproteasome expression and imply a special role of immunoproteasomes in immune cells. Immune cells from human peripheral blood and immune cells from murine spleen have been analyzed for their proteasome composition. All analyzed immune populations express almost solely immunoproteasome subunits and rather small proportions of standard proteasome subunits. This implicates a specialized role for the immunoproteasome in immune cells.
  • Editor: Weinheim: Wiley Subscription Services, Inc
  • Idioma: Inglês;Italiano
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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