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antibacterial activity, antioxidant activity and selectivity index of leaf extracts of thirteen South African tree species used in ethnoveterinary medicine to treat helminth infections

Adamu, Mathew ; Naidoo, Vinny ; Eloff, Jacobus N

BMC veterinary research, 2014-03, Vol.10 (1), p.52-52, Article 52 [Periódico revisado por pares]

England: Springer-Verlag

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Título:
antibacterial activity, antioxidant activity and selectivity index of leaf extracts of thirteen South African tree species used in ethnoveterinary medicine to treat helminth infections
Autor: Adamu, Mathew ; Naidoo, Vinny ; Eloff, Jacobus N
Assuntos: acetone ; Animal diseases ; Animals ; anthelmintics ; Anti-Bacterial Agents - pharmacology ; antibacterial properties ; Antibiotics ; antioxidant activity ; Antioxidants ; Antioxidants - metabolism ; Bacteria ; Bacteria - drug effects ; cytotoxicity ; Enterococcus faecalis ; Escherichia coli ; Ethnobotany ; Flowers & plants ; Free radicals ; Health aspects ; Helminthiasis, Animal - drug therapy ; helminths ; herbal medicines ; humans ; leaf extracts ; Leaves ; livestock ; Maesa ; Medicine, Traditional ; Methods ; Microbial Sensitivity Tests ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Leaves - chemistry ; polar compounds ; Pseudomonas aeruginosa ; South Africa ; Staphylococcus aureus ; Strychnos ; Studies ; trees ; Veterinary Drugs ; Veterinary medicine
É parte de: BMC veterinary research, 2014-03, Vol.10 (1), p.52-52, Article 52
Notas: http://dx.doi.org/10.1186/1746-6148-10-52
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Descrição: BACKGROUND: Diseases caused by bacteria remain a major challenge globally and particularly in sub-Saharan Africa. The plants used in this study have been used in South Africa to treat helminth infections in livestock and humans. In a previous study we found a correlation between antifungal and anthelmintic activity in some cases. In this study we examined other potential uses of these thirteen plant species by determining the antibacterial and antioxidant activity of the leaf acetone extracts. The antibacterial activity was determined by using a serial microdilution method against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Enterococcus faecalis. Bioautography was used to determine the number of antibacterial compounds. The antioxidant activity was determined using the ABTS and DPPH methods. RESULTS: Maesa lanceolata and Leucosidea sericea with an MIC of 0.02 mg/ml had excellent antibacterial activity against Enterococcus faecalis and Pseudomonas aeruginosa. There was a poor correlation between antioxidant activity and antibacterial activity with R² = 0.143. This is because antibacterial activity is mainly related to non-polar compounds and antioxidant activity to polar compounds. Maesa lanceolata extracts had a low cytotoxicity with a selectivity index of 5.2, 2.6, 2.6 and 1.3 for P. aeruginosa, E. faecalis, E. coli and S. aureus respectively. Strychnos mitis extracts had a therapeutic index of 1.1 for E. coli. CONCLUSIONS: This study shows that plant extracts of some species used in ethnoveterinary medicine as anthelmintic may also have excellent antibacterial activity.
Editor: England: Springer-Verlag
Idioma: Inglês

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antibacterial activity, antioxidant activity and selectivity index of leaf extracts of thirteen South African tree species used in ethnoveterinary medicine to treat helminth infections

Adamu, Mathew ; Naidoo, Vinny ; Eloff, Jacobus N

England: Springer-Verlag

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