Idioma:

Long‐term risk of upper gastrointestinal bleeding after Helicobacter pylori eradication: a population‐based cohort study

Jiang, Fang ; Guo, Chuan‐Guo ; Cheung, Ka Shing ; Leung, Wai K.

Alimentary pharmacology & therapeutics, 2021-11, Vol.54 (9), p.1162-1169 [Periódico revisado por pares]

England: Wiley Subscription Services, Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Long‐term risk of upper gastrointestinal bleeding after Helicobacter pylori eradication: a population‐based cohort study
Autor: Jiang, Fang ; Guo, Chuan‐Guo ; Cheung, Ka Shing ; Leung, Wai K.
Assuntos: age ; Anti-Bacterial Agents - adverse effects ; antibiotics ; Bleeding ; Clarithromycin ; Clarithromycin - adverse effects ; Cohort analysis ; Cohort Studies ; Drug Therapy, Combination ; Endoscopy ; Gastrointestinal Hemorrhage - chemically induced ; Gastrointestinal Hemorrhage - epidemiology ; Helicobacter Infections - complications ; Helicobacter Infections - drug therapy ; Helicobacter Infections - epidemiology ; Helicobacter pylori ; Humans ; Middle Aged ; Patients ; Population studies ; Population-based studies ; population‐based study ; upper gastrointestinal bleeding
É parte de: Alimentary pharmacology & therapeutics, 2021-11, Vol.54 (9), p.1162-1169
Notas: The Handling Editor for this article was Dr Colin Howden, and it was accepted for publication after full peer‐review.
Descrição: Summary Background The long‐term effects of H. pylori eradication in preventing upper GI bleeding (UGIB) remains unknown. Aim To determine the long‐term risks of UGIB after H. pylori eradication Methods We included all patients who had received clarithromycin‐containing triple therapy for the treatment of H. pyliori infection between 2003 and 2012, without subsequent need for re‐treatment. We included a propensity score (PS)‐matched endoscopy cohort of H. pylori‐negative patients as controls. The primary endpoint was the risk of subsequent UGIB. A multivariable Cox model was used to compute the hazard ratio (HR) of UGIB. Results We included 62 738 H. pylori‐eradicated and 62 738 PS‐matched H. pylori‐negative patients, with a median follow‐up of 8.1 years (IQR 5.5‐10.6). The incidence of UGIB was 20.8 (95% CI 19.5‐22.1) and 13.6 (95% CI 12.7‐14.7) per 10 000 person‐years in H. pylori‐eradicated and H. pylori‐negative patients, respectively. Compared to controls, H. pylori‐eradicated patients had a significantly higher risk of UGIB (HR: 1.65, 95% CI 1.49‐1.83). The risk of UGIB in H. pylori‐eradicated patients increased after the first 2 years of follow up (HR: 2.18, 95% CI 1.91‐2.49). Age‐stratified analysis showed that patients >45 years had higher UGIB risk, even after eradication. Conclusions Despite H. pylori eradication, the long‐term risk of UGIB was still higher than in H. pylori‐negative control subjects. The protective effects of eradication therapy in preventing UGIB appeared to be limited to younger patients, and to within the first 2 years after eradication. Despite H. pylori eradication, the long‐term risk of UGIB was still higher than H. pylori‐negative subjects. The protective effects of H. pylori eradication in preventing UGIB appeared to belimited to within the first 2 years after eradication.
Editor: England: Wiley Subscription Services, Inc
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Long‐term risk of upper gastrointestinal bleeding after Helicobacter pylori eradication: a population‐based cohort study

Jiang, Fang ; Guo, Chuan‐Guo ; Cheung, Ka Shing ; Leung, Wai K.

England: Wiley Subscription Services, Inc

Buscando em bases de dados remotas. Favor aguardar.