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Performance of Plasma HSP90[alpha], Serum EBV VCA IgA Antibody and Plasma EBV DNA for the Diagnosis and Prognosis Prediction of Nasopharyngeal Carcinoma

Ye, Qian ; Guo, Junying ; Chen, Yansong ; Cui, Zhaolei ; Chen, Yan

Cancer management and research, 2021-07, Vol.13, p.5793 [Periódico revisado por pares]

Dove Medical Press Limited

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  • Título:
    Performance of Plasma HSP90[alpha], Serum EBV VCA IgA Antibody and Plasma EBV DNA for the Diagnosis and Prognosis Prediction of Nasopharyngeal Carcinoma
  • Autor: Ye, Qian ; Guo, Junying ; Chen, Yansong ; Cui, Zhaolei ; Chen, Yan
  • Assuntos: Cancer ; Carcinoma ; DNA ; Enzyme-linked immunosorbent assay ; Genetic aspects ; Heat shock proteins ; Immunoglobulin A ; Prognosis
  • É parte de: Cancer management and research, 2021-07, Vol.13, p.5793
  • Descrição: Objective: The aim of this study was to evaluate the effectiveness of Epstein--Barr virus (EBV) VCA-IgA antibody, EBV DNA and HSP90[alpha] alone or in combinations for the diagnosis and prognostic prediction of nasopharyngeal carcinoma (NPC). Methods: A total of 113 treatment-naive patients with NPC and 40 healthy controls were enrolled. Plasma HSP90[alpha] and serum EBV VCA IgA antibody were detected using ELISA, and plasma EBV DNA was quantified using qPCR assay. The effectiveness of plasma HSP90[alpha] level, serum EBV VCA IgA antibody and plasma EBV DNA was examined in the diagnosis and prognosis prediction of NPC. Results: Higher plasma HSP90[alpha], serum EBV VCA IgA antibody and plasma viral load of EBV DNA were detected in NPC patients than in healthy controls (P < 0.001). The plasma HSP90[alpha] levels, serum EBV VCA IgA antibody titers and plasma viral load of EBV DNA were significantly greater in NPC patients with stages III and IV than in those with stages I and II (P < 0.001), and significantly lower plasma HSP90[alpha] levels, serum EBV VCA IgA antibody titers and plasma viral load of EBV DNA were found in the good prognosis group than in the poor prognosis group post-treatment (P < 0.05). The area under representative operating curves (AUCs) of plasma HSP90[alpha], serum EBV VCA IgA antibody and plasma EBV DNA alone and in combination were 0.884, 0.841, 0.934 and 0.954 for the diagnosis of NPC, respectively. Univariate and multivariate Cox proportional hazards regression analyses identified HSP90[alpha] as an independent prognostic factor for NPC. Conclusion: The combination of plasma HSP90[alpha], serum EBV VCA IgA antibody and plasma EBV DNA shows high diagnostic performance for NPC, and plasma HSP90[alpha] may be a potential marker for diagnosis and prognosis prediction of NPC. Keywords: nasopharyngeal carcinoma, EBV VCA-IgA antibody, EBV DNA, HSP90[alpha], diagnostic performance, prognosis prediction
  • Editor: Dove Medical Press Limited
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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