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Iatrogenic Creutzfeldt-Jakob disease following human growth hormone therapy: case report

Caboclo, Luís Otávio Sales Ferreira ; Huang, Nancy ; Lepski, Guilherme Alves ; Livramento, José Antônio ; Buchpiguel, Carlos Alberto ; Porto, Cláudia Sellitto ; Nitrini, Ricardo

Arquivos de neuro-psiquiatria, 2002-06, Vol.60 (2-B), p.458-461 [Periódico revisado por pares]

Brazil: Academia Brasileira de Neurologia - ABNEURO

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Título:
Iatrogenic Creutzfeldt-Jakob disease following human growth hormone therapy: case report
Autor: Caboclo, Luís Otávio Sales Ferreira ; Huang, Nancy ; Lepski, Guilherme Alves ; Livramento, José Antônio ; Buchpiguel, Carlos Alberto ; Porto, Cláudia Sellitto ; Nitrini, Ricardo
Assuntos: 14-3-3 Proteins ; Adult ; Blotting, Western ; Cerebrospinal Fluid Proteins - analysis ; Creutzfeldt- Jakob disease ; Creutzfeldt-Jakob Syndrome - cerebrospinal fluid ; Creutzfeldt-Jakob Syndrome - diagnosis ; Creutzfeldt-Jakob Syndrome - etiology ; CSF 14-3-3 protein ; diffusion MRI ; growth hormone ; Human Growth Hormone - adverse effects ; Human Growth Hormone - therapeutic use ; Humans ; Iatrogenic Disease ; iatrogenic form ; Magnetic Resonance Imaging ; Male ; NEUROSCIENCES ; PSYCHIATRY ; Tyrosine 3-Monooxygenase - cerebrospinal fluid
É parte de: Arquivos de neuro-psiquiatria, 2002-06, Vol.60 (2-B), p.458-461
Notas: ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
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Descrição: We report the case of a 41-year-old man with iatrogenic Creutzfeldt-Jakob disease (CJD) acquired after the use of growth hormone (GH) obtained from a number of pituitary glands sourced from autopsy material. The incubation period of the disease (from the midpoint of treatment to the onset of clinical symptoms) was rather long (28 years). Besides the remarkable cerebellar and mental signs, the patient exhibited sleep disturbance (excessive somnolence) from the onset of the symptoms, with striking alteration of the sleep architecture documented by polysomnography. 14-3-3 protein was detected in the CSF, and MRI revealed increased signal intensity bilaterally in the striatum, being most evident in diffusion-weighted (DW-MRI) sequences. This is the second case of iatrogenic CJD associated with the use of GH reported in Brazil.
Editor: Brazil: Academia Brasileira de Neurologia - ABNEURO
Idioma: Inglês;Português

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Iatrogenic Creutzfeldt-Jakob disease following human growth hormone therapy: case report

Caboclo, Luís Otávio Sales Ferreira ; Huang, Nancy ; Lepski, Guilherme Alves ; Livramento, José Antônio ; Buchpiguel, Carlos Alberto ; Porto, Cláudia Sellitto ; Nitrini, Ricardo

Brazil: Academia Brasileira de Neurologia - ABNEURO

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