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Palladium Hydride-Enabled Hydroalkenylation of Strained Molecules

Zhang, Ziyan ; Gevorgyan, Vladimir

Journal of the American Chemical Society, 2022-11, Vol.144 (45), p.20875-20883 [Periódico revisado por pares]

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Título:
Palladium Hydride-Enabled Hydroalkenylation of Strained Molecules
Autor: Zhang, Ziyan ; Gevorgyan, Vladimir
Assuntos: Catalysis ; Cyclobutanes ; Palladium - chemistry ; Stereoisomerism
É parte de: Journal of the American Chemical Society, 2022-11, Vol.144 (45), p.20875-20883
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: We report the first palladium hydride enabled hydroalkenylation of strained molecules. This new mild protocol proceeds via a regio- and chemoselective hydropalladation step, followed by a photoinduced radical alkyl Heck reaction. This methodology represents a new reactivity mode for strained molecules and opens new avenues for photoinduced palladium catalysis. The reaction is compatible with a wide range of functional groups and can be applied to complex structures, delivering a diverse array of highly valuable and modifiable alkenylated cyclobutanes and cyclopropanes. A hydroalkenylation/diastereoselective rearrangement cascade toward a cyclopentene scaffold has also been demonstrated.
Editor: United States: American Chemical Society
Idioma: Inglês

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