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Staphylococcus aureus Isolated from Skin from Atopic-Dermatitis Patients Produces Staphylococcal Enterotoxin Y, Which Predominantly Induces T-Cell Receptor Vα-Specific Expansion of T Cells

Aziz, Fatkhanuddin ; Hisatsune, Junzo ; Yu, Liansheng ; Kajimura, Junko ; Sato'o, Yusuke ; Ono, Hisaya K ; Masuda, Kanako ; Yamaoka, Mika ; Salasia, Siti Isrina Oktavia ; Nakane, Akio ; Ohge, Hiroki ; Kusunoki, Yoichiro ; Sugai, Motoyuki Torres, Victor J.

Infection and immunity, 2020-01, Vol.88 (2) [Periódico revisado por pares]

United States: American Society for Microbiology

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Staphylococcus aureus Isolated from Skin from Atopic-Dermatitis Patients Produces Staphylococcal Enterotoxin Y, Which Predominantly Induces T-Cell Receptor Vα-Specific Expansion of T Cells
Autor: Aziz, Fatkhanuddin ; Hisatsune, Junzo ; Yu, Liansheng ; Kajimura, Junko ; Sato'o, Yusuke ; Ono, Hisaya K ; Masuda, Kanako ; Yamaoka, Mika ; Salasia, Siti Isrina Oktavia ; Nakane, Akio ; Ohge, Hiroki ; Kusunoki, Yoichiro ; Sugai, Motoyuki
Torres, Victor J.
Assuntos: Cell Proliferation ; Cluster Analysis ; Dermatitis, Atopic - complications ; Enterotoxins - analysis ; Enterotoxins - genetics ; Enterotoxins - immunology ; Genotype ; Humans ; Japan ; Molecular Pathogenesis ; Molecular Typing ; Receptors, Antigen, T-Cell - analysis ; Skin - microbiology ; Staphylococcal Infections - immunology ; Staphylococcal Infections - microbiology ; Staphylococcus aureus - classification ; Staphylococcus aureus - genetics ; Staphylococcus aureus - immunology ; Staphylococcus aureus - isolation & purification ; T-Lymphocyte Subsets - chemistry ; T-Lymphocyte Subsets - immunology
É parte de: Infection and immunity, 2020-01, Vol.88 (2)
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SourceType-Scholarly Journals-1
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Citation Aziz F, Hisatsune J, Yu L, Kajimura J, Sato’o Y, Ono HK, Masuda K, Yamaoka M, Salasia SIO, Nakane A, Ohge H, Kusunoki Y, Sugai M. 2020. Staphylococcus aureus isolated from skin from atopic-dermatitis patients produces staphylococcal enterotoxin Y, which predominantly induces T-cell receptor Vα-specific expansion of T cells. Infect Immun 88:e00360-19. https://doi.org/10.1128/IAI.00360-19.
Descrição: While investigating the virulence traits of adhering to the skin of atopic-dermatitis (AD) patients, we identified a novel open reading frame (ORF) with structural similarity to a superantigen from genome sequence data of an isolate from AD skin. Concurrently, the same ORF was identified in a bovine isolate of and designated SElY (H. K. Ono, Y. Sato'o, K. Narita, I. Naito, et al., Appl Environ Microbiol 81:7034-7040, 2015, https://doi.org/10.1128/AEM.01873-15). Recombinant SElY had superantigen activity in human peripheral blood mononuclear cells. It further demonstrated emetic activity in a primate animal model, and it was proposed that SElY be renamed SEY (H. K. Ono, S. Hirose, K. Narita, M. Sugiyama, et al., PLoS Pathog 15:e1007803, 2019, https://doi.org/10.1371/journal.ppat.1007803). Here, we investigated the prevalence of the gene in 270 human clinical isolates of various origins in Japan. Forty-two strains were positive for the gene, and the positive isolates were from patients with the skin diseases atopic dermatitis and impetigo/staphylococcal scalded skin syndrome (SSSS), with a detection rate of ∼17 to 22%. There were three variants of SEY (SEY , SEY , and SEY ), and isolates producing SEY variants formed three distinct clusters corresponding to clonal complexes (CCs) 121, 59, and 20, respectively. Most isolates produced SEY in broth culture. Unlike SEY , the three recombinant SEY variants exhibited stability against heat treatment. SEY predominantly activated human T cells with a particular T-cell receptor (TCR) Vα profile, a unique observation since most staphylococcal enterotoxins exert their superantigenic activities through activating T cells with specific TCR Vβ profiles. SEY may act to induce localized inflammation via skin-resident T-cell activation, facilitating the pathogenesis of infection in disrupted epithelial barriers.
Editor: United States: American Society for Microbiology
Idioma: Inglês

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Staphylococcus aureus Isolated from Skin from Atopic-Dermatitis Patients Produces Staphylococcal Enterotoxin Y, Which Predominantly Induces T-Cell Receptor Vα-Specific Expansion of T Cells

Aziz, Fatkhanuddin ; Hisatsune, Junzo ; Yu, Liansheng ; Kajimura, Junko ; Sato'o, Yusuke ; Ono, Hisaya K ; Masuda, Kanako ; Yamaoka, Mika ; Salasia, Siti Isrina Oktavia ; Nakane, Akio ; Ohge, Hiroki ; Kusunoki, Yoichiro ; Sugai, Motoyuki Torres, Victor J.

United States: American Society for Microbiology

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