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Within-host genetic diversity of SARS-CoV-2 lineages in unvaccinated and vaccinated individuals

Gu, Haogao ; Quadeer, Ahmed Abdul ; Krishnan, Pavithra ; Ng, Daisy Y M ; Chang, Lydia D J ; Liu, Gigi Y Z ; Cheng, Samuel M S ; Lam, Tommy T Y ; Peiris, Malik ; McKay, Matthew R ; Poon, Leo L M

Nature communications, 2023-03, Vol.14 (1), p.1793-1793, Article 1793 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Within-host genetic diversity of SARS-CoV-2 lineages in unvaccinated and vaccinated individuals
Autor: Gu, Haogao ; Quadeer, Ahmed Abdul ; Krishnan, Pavithra ; Ng, Daisy Y M ; Chang, Lydia D J ; Liu, Gigi Y Z ; Cheng, Samuel M S ; Lam, Tommy T Y ; Peiris, Malik ; McKay, Matthew R ; Poon, Leo L M
Assuntos: Amino acid sequence ; Antibodies ; Antibodies, Viral ; Breakthrough Infections ; COVID-19 - epidemiology ; COVID-19 - prevention & control ; COVID-19 Vaccines ; Disease control ; Evolution ; Genetic diversity ; Genetic variation ; Genomes ; Humans ; Immunization ; Infections ; Lymphocytes ; Lymphocytes T ; Mutation ; Protein sequencing ; Respiration ; SARS-CoV-2 - genetics ; Sequencing ; Severe acute respiratory syndrome coronavirus 2 ; Vaccination ; Vaccines
É parte de: Nature communications, 2023-03, Vol.14 (1), p.1793-1793, Article 1793
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Viral and host factors can shape SARS-CoV-2 evolution. However, little is known about lineage-specific and vaccination-specific mutations that occur within individuals. Here, we analysed deep sequencing data from 2,820 SARS-CoV-2 respiratory samples with different viral lineages to describe the patterns of within-host diversity under different conditions, including vaccine-breakthrough infections. In unvaccinated individuals, variant of Concern (VOC) Alpha, Delta, and Omicron respiratory samples were found to have higher within-host diversity and were under neutral to purifying selection at the full genome level compared to non-VOC SARS-CoV-2. Breakthrough infections in 2-dose or 3-dose Comirnaty and CoronaVac vaccinated individuals did not increase levels of non-synonymous mutations and did not change the direction of selection pressure. Vaccine-induced antibody or T cell responses did not appear to have significant impact on within-host SARS-CoV-2 sequence diversification. Our findings suggest that vaccination does not increase exploration of SARS-CoV-2 protein sequence space and may not facilitate emergence of viral variants.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Within-host genetic diversity of SARS-CoV-2 lineages in unvaccinated and vaccinated individuals

Gu, Haogao ; Quadeer, Ahmed Abdul ; Krishnan, Pavithra ; Ng, Daisy Y M ; Chang, Lydia D J ; Liu, Gigi Y Z ; Cheng, Samuel M S ; Lam, Tommy T Y ; Peiris, Malik ; McKay, Matthew R ; Poon, Leo L M

England: Nature Publishing Group

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