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Clinical pancreatic islet transplantation

Shapiro, A M James ; Pokrywczynska, Marta ; Ricordi, Camillo

Nature reviews. Endocrinology, 2017-05, Vol.13 (5), p.268-277 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Clinical pancreatic islet transplantation
Autor: Shapiro, A M James ; Pokrywczynska, Marta ; Ricordi, Camillo
Assuntos: Animals ; Clinical trials ; Clinical Trials, Phase III as Topic - methods ; Diabetes ; Diabetes Mellitus, Type 1 - diagnosis ; Diabetes Mellitus, Type 1 - metabolism ; Diabetes Mellitus, Type 1 - therapy ; Health aspects ; Humans ; Hypoglycemia ; Insulin resistance ; Islands of Langerhans ; Islet cell transplantation ; Islets of Langerhans ; Islets of Langerhans - metabolism ; Islets of Langerhans Transplantation - adverse effects ; Islets of Langerhans Transplantation - methods ; Multicenter Studies as Topic - methods ; Pancreas Transplantation - adverse effects ; Pancreas Transplantation - methods ; Patients ; Transplants & implants
É parte de: Nature reviews. Endocrinology, 2017-05, Vol.13 (5), p.268-277
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
Descrição: Clinical pancreatic islet transplantation can be considered one of the safest and least invasive transplant procedures. Remarkable progress has occurred in both the technical aspects of islet cell processing and the outcomes of clinical islet transplantation. With >1,500 patients treated since 2000, this therapeutic strategy has moved from a curiosity to a realistic treatment option for selected patients with type 1 diabetes mellitus (that is, those with hypoglycaemia unawareness, severe hypoglycaemic episodes and glycaemic lability). This Review outlines the techniques required for human islet isolation, in vitro culture before the transplant and clinical islet transplantation, and discusses indications, optimization of recipient immunosuppression and management of adjunctive immunomodulatory and anti-inflammatory strategies. The potential risks, long-term outcomes and advances in treatment after the transplant are also discussed to further move this treatment towards becoming a more widely available option for patients with type 1 diabetes mellitus and eventually a potential cure.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Clinical pancreatic islet transplantation

Shapiro, A M James ; Pokrywczynska, Marta ; Ricordi, Camillo

England: Nature Publishing Group

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