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Convergence of chromogranin and amyloid metabolism in the brain

Mattsson, Niklas ; Johansson, Per ; Hansson, Oskar ; Wallin, Anders ; Johansson, Jan-Ove ; Andreasson, Ulf ; Andersen, Oluf ; Haghighi, Sara ; Olsson, Maria ; Stridsberg, Mats ; Svensson, Johan ; Blennow, Kaj ; Zetterberg, Henrik

Alzheimer's & dementia, 2010, Vol.6 (4), p.S511-S511 [Periódico revisado por pares]

Elsevier Inc

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  • Título:
    Convergence of chromogranin and amyloid metabolism in the brain
  • Autor: Mattsson, Niklas ; Johansson, Per ; Hansson, Oskar ; Wallin, Anders ; Johansson, Jan-Ove ; Andreasson, Ulf ; Andersen, Oluf ; Haghighi, Sara ; Olsson, Maria ; Stridsberg, Mats ; Svensson, Johan ; Blennow, Kaj ; Zetterberg, Henrik
  • Assuntos: Basic Medicine ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Medicinska och farmaceutiska grundvetenskaper ; Neurology ; Neurosciences ; Neurovetenskaper
  • É parte de: Alzheimer's & dementia, 2010, Vol.6 (4), p.S511-S511
  • Descrição: Background: Much is unknown regarding the regulation of amyloid precursor protein (APP) processing in the human central nervous system. It has been hypothesized that amyloidogenic APP-processing preferentially occurs in the regulated secretory pathway of neurons. To test this hypothesis we looked for correlations of APP-derived molecules in CSF with chromogranin (Cg) derived peptides, representing the regulated secretion. Methods: Patients with Alzheimer's disease (AD, N = 32), multiple sclerosis (MS, N = 50) and healthy controls (N = 70) were enrolled. CSF was analyzed for the amyloid peptides Aβ1-42, Aβx-42, Aβx-40, Aβx-38, α-cleaved soluble APP (α-sAPP), β-cleaved soluble APP (β-sAPP), and peptides derived from CgB and SgII (Secretogranin-II, CgC). We investigated CSF levels of the protease BACE1, which processes APP into Aβ, in relation to Cg-levels. Finally, we measured Cg levels in cell media from untreated and BACE1-inhibited SH-SY5Y human neuroblastoma cells. Results: CSF Cg levels correlated to sAPP and Aβ peptides in AD, MS and controls, and to CSF BACE1. Cell medium from BACE1-inhibited cells had decreased CgB levels. Conclusions: These results suggest that a large part of APP in the human central nervous system is processed in the regulated secretory pathway of neurons.
  • Editor: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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