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An extract of Polygonum multiflorum protects against free radical damage induced by ultraviolet B irradiation of the skin

Hwang, I K ; Yoo, K-Y ; Kim, D W ; Jeong, S J ; Won, C-K ; Moon, W-K ; Kim, Y S ; Kwon, D Y ; Won, M H ; Kim, D-W

Brazilian journal of medical and biological research, 2006-09, Vol.39 (9), p.1181-1188 [Periódico revisado por pares]

Brazil: Associação Brasileira de Divulgação Científica

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Título:
An extract of Polygonum multiflorum protects against free radical damage induced by ultraviolet B irradiation of the skin
Autor: Hwang, I K ; Yoo, K-Y ; Kim, D W ; Jeong, S J ; Won, C-K ; Moon, W-K ; Kim, Y S ; Kwon, D Y ; Won, M H ; Kim, D-W
Assuntos: Administration, Topical ; Animals ; Antioxidants - therapeutic use ; BIOLOGY ; Blotting, Western ; Cu,Zn-superoxide dismutase ; Female ; Free radicals ; Hairless mouse ; MEDICINE, RESEARCH & EXPERIMENTAL ; Mice ; Mice, Hairless ; Plant Extracts - therapeutic use ; Polygonum - chemistry ; Polygonum multiflorum extract ; Radiation Injuries, Experimental - metabolism ; Radiation Injuries, Experimental - prevention & control ; Skin ; Skin - radiation effects ; Superoxide Dismutase - metabolism ; Superoxide Dismutase-1 ; Ultraviolet B irradiation ; Ultraviolet Rays - adverse effects
É parte de: Brazilian journal of medical and biological research, 2006-09, Vol.39 (9), p.1181-1188
Descrição: Over the last decades, the incidence of ultraviolet B (UVB)-related skin problems has been increasing. Damages induced by UVB radiation are related to mutations that occur as a result of direct DNA damage and/or the production of reactive oxygen species. We investigated the anti-oxidant effects of a Polygonum multiflorum thumb extract against skin damage induced by UVB irradiation. Female SKH-1 hairless mice were divided into three groups: control (N = 7), distilled water- (N = 10), and P. multiflorum extract-treated (PM, N = 10) groups. The PM (10 g) was extracted with 100 mL distilled water, cryo-dried and 9.8 g was obtained. The animals received a topical application of 500 microL distilled water or PM extract (1, 2, 4, 8, and 16%, w/v, dissolved in distilled water) for 30 min after UVB irradiation (wavelength 280-320 nm, 300 mJ/cm(2); 3 min) of the dorsal kin for 14 days, and skin immunohistochemistry and Cu,Zn-superoxide dismutase (SOD1) activity were determined. SOD1 immunoreactivity, its protein levels and activities in the skin were significantly reduced by 70% in the distilled water-treated group after UVB irradiation compared to control. However, in the PM extract-treated groups, SOD1 immunoreactivity and its protein and activity levels increased in a dose-dependent manner (1-16%, w/v, PM extract) compared to the distilled water-treated group. SOD1 protein levels and activities in the groups treated with 8 and 16%, w/v, PM extract recovered to 80-90% of the control group levels after UVB. These results suggest that PM extract strongly inhibits the destruction of SOD1 by UV radiation and probably contains anti-skin photoaging agents.
Editor: Brazil: Associação Brasileira de Divulgação Científica
Idioma: Inglês;Português

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An extract of Polygonum multiflorum protects against free radical damage induced by ultraviolet B irradiation of the skin

Hwang, I K ; Yoo, K-Y ; Kim, D W ; Jeong, S J ; Won, C-K ; Moon, W-K ; Kim, Y S ; Kwon, D Y ; Won, M H ; Kim, D-W

Brazil: Associação Brasileira de Divulgação Científica

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