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Advanced biomaterial agent from chitosan/poloxamer 407-based thermosensitive hydrogen containing biosynthesized silver nanoparticles using Eucalyptus camaldulensis leaf extract

Wunnoo, Suttiwan ; Lorenzo-Leal, Ana C ; Voravuthikunchai, Supayang P ; Bach, Horacio Xu, Bing

PloS one, 2023-10, Vol.18 (10), p.e0291505-e0291505 [Periódico revisado por pares]

San Francisco, CA USA: Public Library of Science

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  • Título:
    Advanced biomaterial agent from chitosan/poloxamer 407-based thermosensitive hydrogen containing biosynthesized silver nanoparticles using Eucalyptus camaldulensis leaf extract
  • Autor: Wunnoo, Suttiwan ; Lorenzo-Leal, Ana C ; Voravuthikunchai, Supayang P ; Bach, Horacio
  • Xu, Bing
  • Assuntos: Bacterial infections ; Biological products ; Biology and Life Sciences ; Care and treatment ; Cells ; Drug resistance in microorganisms ; Eucalyptus ; Health aspects ; Hydrogen ; Inflammation ; Materia medica, Vegetable ; Medicine and Health Sciences ; Medicine, Botanic ; Medicine, Herbal ; Nanoparticles ; Physical Sciences ; Plant extracts ; Properties ; Public health ; Silver ; Tazobactam
  • É parte de: PloS one, 2023-10, Vol.18 (10), p.e0291505-e0291505
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Competing Interests: The authors have declared that no competing interests exist.
  • Descrição: The emergence of multidrug-resistant (MDR) pathogens poses a significant challenge for global public health systems, increasing hospital morbidity and mortality and prolonged hospitalization. We evaluated the antimicrobial activity of a thermosensitive hydrogel containing bio-synthesized silver nanoparticles (bio-AgNPs) based on chitosan/poloxamer 407 using a leaf extract of Eucalyptus calmadulensis. The thermosensitive hydrogel was prepared by a cold method after mixing the ingredients and left at 4°C overnight to ensure the complete solubilization of poloxamer 407. The stability of the hydrogel formulation was evaluated at room temperature for 3 months, and the absorption peak (420 nm) of the NPs remained unchanged. The hydrogel formulation demonstrated rapid gelation under physiological conditions, excellent water retention (85%), and broad-spectrum antimicrobial activity against MDR clinical isolates and ATCC strains. In this regard, minimum inhibitory concentration and minimum microbial concentration values of the bio-AgNPs ranged from 2-8 [mu]g/mL to 8-128 [mu]g/mL, respectively. Formulation at concentrations <64 [mu]g/mL showed no cytotoxic effect on human-derived macrophages (THP-1 cells) with no induction of inflammation. The formulated hydrogel could be used in biomedical applications as it possesses a broad antimicrobial spectrum and anti-inflammatory properties without toxic effects on human cells.
  • Editor: San Francisco, CA USA: Public Library of Science
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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