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18:0 Lyso PC Derived by Bioactivity-Based Molecular Networking from Lentil Mutant Lines and Its Effects on High-Fat Diet-Induced Obese Mice

Han, Ah-Reum ; Park, Hae Ran ; Kim, Geum Jin ; Kim, Bo-Ram ; Kim, Ye-Ram ; Park, Hyeon Hwa ; Park, Jisu ; Jin, Chang Hyun ; Kim, Jung Min ; Kwon, Soon-Jae ; Kim, Jin-Baek ; Cao, Shugeng ; Nam, Joo-Won ; Choi, Hyukjae

Molecules (Basel, Switzerland), 2021-12, Vol.26 (24), p.7547 [Periódico revisado por pares]

Switzerland: MDPI AG

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18:0 Lyso PC Derived by Bioactivity-Based Molecular Networking from Lentil Mutant Lines and Its Effects on High-Fat Diet-Induced Obese Mice
Autor: Han, Ah-Reum ; Park, Hae Ran ; Kim, Geum Jin ; Kim, Bo-Ram ; Kim, Ye-Ram ; Park, Hyeon Hwa ; Park, Jisu ; Jin, Chang Hyun ; Kim, Jung Min ; Kwon, Soon-Jae ; Kim, Jin-Baek ; Cao, Shugeng ; Nam, Joo-Won ; Choi, Hyukjae
Assuntos: 18:0 Lyso PC ; Adipocytes ; Adipocytes - metabolism ; Adipose tissue ; Adipose Tissue - metabolism ; Animals ; Annotations ; Anti-Obesity Agents - chemistry ; Anti-Obesity Agents - pharmacology ; Biological activity ; Body fat ; Body weight ; Body weight gain ; Cholesterol ; Cholesterol, LDL - blood ; Cultivars ; Diet ; Diet, High-Fat - adverse effects ; Fabaceae ; Flavonoids ; Gamma irradiation ; Genetic diversity ; Glucagon ; High density lipoprotein ; High fat diet ; Hybridization ; In vivo methods and tests ; Insulin ; Irradiation ; LC-MS/MS ; Lecithin ; Lens culinaris ; Lens Plant - chemistry ; Lens Plant - genetics ; lentil ; Leptin ; Lipids ; Liver ; Low density lipoprotein ; Male ; Metabolites ; Mice ; Minerals ; molecular networking ; Mutagenesis ; Mutants ; Mutation ; Natural products ; Networking ; Obesity ; Obesity - blood ; Obesity - chemically induced ; Obesity - drug therapy ; Peptides ; Phenolic acids ; Phenols ; Phenotypes ; Phosphatidylcholine ; Phosphatidylcholines - chemistry ; Phosphatidylcholines - genetics ; Phosphatidylcholines - pharmacology ; Phosphocholine ; Plant breeding ; Polyphenols ; Population studies ; Social organization ; Triglycerides ; γ Radiation
É parte de: Molecules (Basel, Switzerland), 2021-12, Vol.26 (24), p.7547
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
These authors contributed equally to this work.
Descrição: Lentil ( ; Fabaceae), one of the major pulse crops in the world, is an important source of proteins, prebiotics, lipids, and essential minerals as well as functional components such as flavonoids, polyphenols, and phenolic acids. To improve crop nutritional and medicinal traits, hybridization and mutation are widely used in plant breeding research. In this study, mutant lentil populations were generated by γ-irradiation for the development of new cultivars by inducing genetic diversity. Molecular networking via Global Natural Product Social Molecular Networking web platform and dipeptidyl peptide-IV inhibitor screening assay were utilized as tools for structure-based discovery of active components in active mutant lines selected among the lentil population. The bioactivity-based molecular networking analysis resulted in the annotation of the molecular class of phosphatidylcholine (PC) from the most active mutant line. Among PCs, 1-stearoyl-2-hydroxy- -glycero-3-phosphocholine (18:0 Lyso PC) was selected for further in vivo study of anti-obesity effect in a high-fat diet (HFD)-induced obese mouse model. The administration of 18:0 Lyso PC not only prevented body weight gain and decreased relative gonadal adipose tissue weight, but also attenuated the levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol, and leptin in the sera of HFD-induced obese mice. Additionally, 18:0 Lyso PC treatment inhibited the increase of adipocyte area and crown-like structures in adipose tissue. Therefore, these results suggest that 18:0 Lyso PC is a potential compound to have protective effects against obesity, improving obese phenotype induced by HFD.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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18:0 Lyso PC Derived by Bioactivity-Based Molecular Networking from Lentil Mutant Lines and Its Effects on High-Fat Diet-Induced Obese Mice

Han, Ah-Reum ; Park, Hae Ran ; Kim, Geum Jin ; Kim, Bo-Ram ; Kim, Ye-Ram ; Park, Hyeon Hwa ; Park, Jisu ; Jin, Chang Hyun ; Kim, Jung Min ; Kwon, Soon-Jae ; Kim, Jin-Baek ; Cao, Shugeng ; Nam, Joo-Won ; Choi, Hyukjae

Switzerland: MDPI AG

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