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Plasticity of prefrontal attention circuitry: upregulated muscarinic excitability in response to decreased nicotinic signaling following deletion of α5 or β2 subunits

Tian, Michael K ; Bailey, Craig D C ; De Biasi, Mariella ; Picciotto, Marina R ; Lambe, Evelyn K

The Journal of neuroscience, 2011-11, Vol.31 (45), p.16458-16463 [Periódico revisado por pares]

United States: Society for Neuroscience

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Título:
Plasticity of prefrontal attention circuitry: upregulated muscarinic excitability in response to decreased nicotinic signaling following deletion of α5 or β2 subunits
Autor: Tian, Michael K ; Bailey, Craig D C ; De Biasi, Mariella ; Picciotto, Marina R ; Lambe, Evelyn K
Assuntos: Acetylcholine - pharmacology ; Aconitine - analogs & derivatives ; Aconitine - pharmacology ; Age Factors ; Analysis of Variance ; Animals ; Atropine - pharmacology ; Brief Communications ; Dihydro-beta-Erythroidine - pharmacology ; Intracellular Signaling Peptides and Proteins - pharmacology ; Male ; Membrane Potentials - drug effects ; Membrane Potentials - genetics ; Mice ; Mice, Knockout ; Neuronal Plasticity - drug effects ; Neuronal Plasticity - genetics ; Neurons - drug effects ; Neurons - physiology ; Neuropeptides - pharmacology ; Neurotransmitter Agents - pharmacology ; Nicotine - metabolism ; Nicotinic Antagonists - pharmacology ; Orexins ; Patch-Clamp Techniques - methods ; Prefrontal Cortex - cytology ; Receptors, Muscarinic - genetics ; Receptors, Muscarinic - metabolism ; Receptors, Nicotinic - deficiency ; Signal Transduction - genetics ; Up-Regulation - genetics
É parte de: The Journal of neuroscience, 2011-11, Vol.31 (45), p.16458-16463
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Author contributions: M.K.T., C.D.C.B., and E.K.L. designed research; M.K.T. and C.D.C.B. performed research; M.D. and M.R.P. contributed unpublished reagents/analytic tools; M.K.T. and E.K.L. analyzed data; M.K.T., C.D.C.B., M.D., M.R.P., and E.K.L. wrote the paper.
Descrição: Attention depends on cholinergic stimulation of nicotinic and muscarinic acetylcholine receptors in the medial prefrontal cortex. Pyramidal neurons in layer VI of this region express cholinergic receptors of both families and play an important role in attention through their feedback projections to the thalamus. Here, we investigate how nicotinic and muscarinic cholinergic receptors affect the excitability of these neurons using whole-cell recordings in acute brain slices of prefrontal cortex. Since attention deficits have been documented in both rodents and humans having genetic abnormalities in nicotinic receptors, we focus in particular on how the cholinergic excitation of layer VI neurons is altered by genetic deletion of either of two key nicotinic receptor subunits, the accessory α5 subunit or the ligand-binding β2 subunit. We find that the cholinergic excitation of layer VI neurons is dominated by nicotinic receptors in wild-type mice and that the reduction or loss of this nicotinic stimulation is accompanied by a surprising degree of plasticity in excitatory muscarinic receptors. These findings suggest that disrupting nicotinic receptors fundamentally alters the mechanisms and timing of excitation in prefrontal attentional circuitry.
Editor: United States: Society for Neuroscience
Idioma: Inglês

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Plasticity of prefrontal attention circuitry: upregulated muscarinic excitability in response to decreased nicotinic signaling following deletion of α5 or β2 subunits

Tian, Michael K ; Bailey, Craig D C ; De Biasi, Mariella ; Picciotto, Marina R ; Lambe, Evelyn K

United States: Society for Neuroscience

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