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Obesity in Pulmonary Arterial Hypertension (PAH): The Pulmonary Hypertension Association Registry (PHAR)

Min, Jeff ; Feng, Rui ; Badesch, David ; Berman-Rosenzweig, Erika ; Burger, Charles ; Chakinala, Murali ; De Marco, Teresa ; Feldman, Jeremy ; Hemnes, Anna ; Horn, Evelyn M ; Lammi, Matthew R ; Mathai, Stephen ; McConnell, John W ; Presberg, Kenneth ; Robinson, Jeffrey ; Sager, Jeffrey ; Shlobin, Oksana A ; Simon, Marc ; Thenappan, Thenappan ; Ventetuolo, Corey ; Al-Naamani, Nadine

Annals of the American Thoracic Society, 2021-02, Vol.18 (2), p.229-237 [Periódico revisado por pares]

United States: American Thoracic Society

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  • Título:
    Obesity in Pulmonary Arterial Hypertension (PAH): The Pulmonary Hypertension Association Registry (PHAR)
  • Autor: Min, Jeff ; Feng, Rui ; Badesch, David ; Berman-Rosenzweig, Erika ; Burger, Charles ; Chakinala, Murali ; De Marco, Teresa ; Feldman, Jeremy ; Hemnes, Anna ; Horn, Evelyn M ; Lammi, Matthew R ; Mathai, Stephen ; McConnell, John W ; Presberg, Kenneth ; Robinson, Jeffrey ; Sager, Jeffrey ; Shlobin, Oksana A ; Simon, Marc ; Thenappan, Thenappan ; Ventetuolo, Corey ; Al-Naamani, Nadine
  • Assuntos: Hospitalization ; Obesity ; Original Research ; Pulmonary hypertension ; Quality of life
  • É parte de: Annals of the American Thoracic Society, 2021-02, Vol.18 (2), p.229-237
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
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  • Descrição: Obesity is associated with pulmonary arterial hypertension (PAH), but its impact on outcomes such as health-related quality of life (HRQoL), hospitalizations and survival is not well understood. To assess the effect of obesity on health-related quality of life (HRQoL), hospitalizations and survival in patients with PAH. We performed a cohort study of adults with PAH from the Pulmonary Hypertension Association Registry, a prospective multicenter registry. Multivariate linear mixed effects regression was used to examine the relationship between weight categories and HRQoL using the Short Form-12 (SF-12) and emPHasis-10 (e10). We used multivariable negative binomial regression to estimate hospitalization incidence rate ratios (IRRs) and Cox regression to estimate hazard ratios (HRs) for transplant-free survival by weight status. 767 subjects were included: mean age of 57 years, 74% female, 33% overweight and 40% obese, with median follow-up duration of 527 days. Overweight and obese patients had higher baseline e10 scores (worse HRQoL), which persisted over time (p<0.001). The overweight and obese have a trend towards increased incidence of hospitalizations compared to normal weight (IRR 1.34, 95% confidence interval (95%CI) 0.94-1.92 and 1.33, 95%CI 0.93-1.89, respectively). Overweight and obese patients had lower risk of transplant or death as compared to normal weight patients (HR 0.45, 95%CI 0.25-0.80 and 0.39, 95%CI 0.22-0.70, respectively). In a large multicenter, prospective cohort of PAH, overweight and obese patients had worse disease-specific HRQoL despite better transplant-free survival compared to normal weight patients. Future interventions should address the specific needs of these patients.
  • Editor: United States: American Thoracic Society
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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