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Roth’s spot in megaloblastic anaemia

Dhibar, Deba Prasad ; Sahu, Kamal Kant ; Jinagal, Jitender ; Jain, Sanjay ; Varma, Subhash Chander

Postgraduate medical journal, 2018-01, Vol.94 (1107), p.66-66 [Periódico revisado por pares]

England: Oxford University Press

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  • Título:
    Roth’s spot in megaloblastic anaemia
  • Autor: Dhibar, Deba Prasad ; Sahu, Kamal Kant ; Jinagal, Jitender ; Jain, Sanjay ; Varma, Subhash Chander
  • Assuntos: Anemia ; Blood ; Diabetic retinopathy ; Hemoglobin ; Retina
  • É parte de: Postgraduate medical journal, 2018-01, Vol.94 (1107), p.66-66
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
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  • Descrição: Investigation revealed pancytopaenia (total leucocyte count: 3.6×109/L, platelet count: 78×109/L) with severe megaloblastic anaemia (haemoglobin: 4.7 g/dL, mean corpuscular volume: 119.5 fL/cell, mean corpuscular haemoglobin: 38.29 pg/cell). Repeat fundus examination revealed no haemorrhage with complete resolution of Roth’s spot (figure 2A, B). Besides subacute bacterial endocarditis, Roth’s spot may also be seen in leukaemia, anaemia, anoxia, carbon monoxide poisoning, hypertension or diabetic retinopathy and pre-eclampsia.1 The exact pathophysiology behind this white-centred retinal haemorrhage is not well established. The most widely accepted theory is that white spot is due to the formation of fibrin platelet thrombus at the site of retinal haemorrhage, following rupture of retinal capillaries.1 2 Roth’s spot in megaloblastic anaemia is rarely reported.3 The proposed mechanism of Roth’s spot in anaemia is ischaemic or anoxic damage to the retinal capillary endothelium leading to retinal haemorrhage.1 Megaloblastic anaemia in our patient was most likely due to vitamin B12 deficiency secondary to inadequate dietary intake, as the primary source of vitamin B12 is animal product, and the anaemia resolved with vitamin B12 therapy.
  • Editor: England: Oxford University Press
  • Idioma: Inglês
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