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iNOS -derived Nitric Oxide Modulates Infection-stimulated Bone Loss

Fukada, S.Y. ; Silva, T.A. ; Saconato, I.F. ; Garlet, G.P. ; Ávila-Campos, M.J. ; Silva, J.S. ; Cunha, F.Q.

Journal of dental research, 2008-12, Vol.87 (12), p.1155-1159 [Periódico revisado por pares]

United States: SAGE Publications

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Título:
iNOS -derived Nitric Oxide Modulates Infection-stimulated Bone Loss
Autor: Fukada, S.Y. ; Silva, T.A. ; Saconato, I.F. ; Garlet, G.P. ; Ávila-Campos, M.J. ; Silva, J.S. ; Cunha, F.Q.
Assuntos: Acid Phosphatase - analysis ; Actinomycosis - enzymology ; Alveolar Bone Loss - enzymology ; Alveolar Bone Loss - pathology ; Animals ; Bacterial Infections - enzymology ; Bacteroidaceae Infections - enzymology ; Biomarkers - analysis ; Cell Count ; Cell Movement ; Chemokine CXCL12 - analysis ; Dental Pulp Exposure - microbiology ; Dentistry ; Isoenzymes - analysis ; Mice ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Nitric Oxide - metabolism ; Nitric Oxide Synthase Type II - metabolism ; Osteoclasts - pathology ; Osteolysis - metabolism ; Osteolysis - pathology ; Osteoprotegerin - analysis ; Periapical Periodontitis - enzymology ; Periapical Periodontitis - pathology ; RANK Ligand - analysis ; Receptor Activator of Nuclear Factor-kappa B - analysis ; Tartrate-Resistant Acid Phosphatase
É parte de: Journal of dental research, 2008-12, Vol.87 (12), p.1155-1159
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Descrição: Nitric oxide (NO) derived from inducible nitric oxide synthase (iNOS) plays an important role in host defense, as well as in inflammation-induced tissue lesions. Here we evaluated the role of NO in bone loss in bacterial infection-induced apical periodontitis by using iNOS-deficient mice (iNOS−/−). The iNOS−/− mice developed greater inflammatory cell recruitment and osteolytic lesions than WT mice. Moreover, tartrate-resistant acid-phosphatase-positive (TRAP+) osteoclasts were significantly more numerous in iNOS−/− mice. Furthermore, the increased bone resorption in iNOS−/− mice also correlated with the increased expression of receptor activator NF-kappaB (RANK), stromal-cell-derived factor-1α (SDF-1α/CXCL12), and reduced expression of osteoprotegerin (OPG). These results show that NO deficiency was associated with an imbalance of bone-resorption-modulating factors, leading to severe infection-stimulated bone loss.
Editor: United States: SAGE Publications
Idioma: Inglês

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iNOS -derived Nitric Oxide Modulates Infection-stimulated Bone Loss

Fukada, S.Y. ; Silva, T.A. ; Saconato, I.F. ; Garlet, G.P. ; Ávila-Campos, M.J. ; Silva, J.S. ; Cunha, F.Q.

United States: SAGE Publications

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