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Different Resistance-Training Regimens Evoked a Similar Increase in Myostatin Inhibitors Expression

Santos, A. R. ; Lamas, L. ; Ugrinowitsch, C. ; Tricoli, V. ; Miyabara, E. H. ; Soares, A. G. ; Aoki, M. S.

International journal of sports medicine, 2015-08, Vol.36 (9), p.761-768 [Periódico revisado por pares]

Stuttgart · New York: Georg Thieme Verlag KG

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  • Título:
    Different Resistance-Training Regimens Evoked a Similar Increase in Myostatin Inhibitors Expression
  • Autor: Santos, A. R. ; Lamas, L. ; Ugrinowitsch, C. ; Tricoli, V. ; Miyabara, E. H. ; Soares, A. G. ; Aoki, M. S.
  • Assuntos: Adult ; Biopsy ; Gene Expression ; Genetics & Molecular Biology ; Humans ; Male ; Muscle Strength - physiology ; Muscle, Skeletal - metabolism ; Myostatin - genetics ; Myostatin - metabolism ; Physical Education and Training - methods ; Real-Time Polymerase Chain Reaction ; Resistance Training - methods ; Signal Transduction ; Young Adult
  • É parte de: International journal of sports medicine, 2015-08, Vol.36 (9), p.761-768
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Abstract The aim of the present study was to investigate the effect of different resistance-training regimens (S or P) on the expression of genes related to the MSTN signaling pathway in physically-active men. 29 male subjects with at least 2 years of experience in strength training were assigned to either a strength-training group (S; n=11) or a power-training group (P; n=11). The control group (C; n=7) was composed of healthy physically-active males. The S and the P groups performed high- and low-intensity squats, respectively, 3 times per week, for 8 weeks. Muscle biopsies from the vastus lateralis muscle were collected before and after the training period. No change was observed in MSTN, ACTIIB, GASP-1 and FOXO-3 A gene expression after the training period. A similar increase in the gene expression of the inhibitory proteins of the MSTN signaling pathway, FLST (S: 4.2 fold induction and P: 3.7 fold induction, p<0.01) and FL-3 (S: 5.6 fold induction and P: 5.6 fold induction, p<0.01), was detected after the training period. SMAD-7 gene expression was similarly augmented after both training protocols (S: 2.5 fold induction; P: 2.8 fold induction; p<0.05). In conclusion, the resistance-training regimens (S and P) activated the expression of inhibitors of the MSTN signaling pathway in a similar manner.
  • Editor: Stuttgart · New York: Georg Thieme Verlag KG
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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