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PLLA biodegradable scaffolds for angiogenesis via Diffusion Induced Phase Separation (DIPS)

La Carrubba, V. ; Carfì Pavia, F. ; Brucato, V. ; Piccarolo, S. ; Ghersi, G.

International journal of material forming, 2008-04, Vol.1 (Suppl 1), p.623-626 [Periódico revisado por pares]

Paris: Springer-Verlag

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  • Título:
    PLLA biodegradable scaffolds for angiogenesis via Diffusion Induced Phase Separation (DIPS)
  • Autor: La Carrubba, V. ; Carfì Pavia, F. ; Brucato, V. ; Piccarolo, S. ; Ghersi, G.
  • Assuntos: CAE) and Design ; Computational Intelligence ; Computer-Aided Engineering (CAD ; Engineering ; Machines ; Manufacturing ; Materials Science ; Mechanical Engineering ; Processes ; Symposium MS10: Structures and properties of polymers
  • É parte de: International journal of material forming, 2008-04, Vol.1 (Suppl 1), p.623-626
  • Descrição: A critical obstacle in tissue engineering is the inability to maintain large masses of living cells upon transfer from the in vitro culture conditions into the host in vivo . Capillaries, and the vascular system, are required to supply essential nutrients, including oxygen, remove waste products and provide a biochemical communication “highway”. For this reason it is mandatory to manufacture an implantable structure where the process of vessel formation – the angiogenesis – can take place. In this work PLLA scaffolds for vascular tissue engineering were produced by dip-coating via Diffusion Induced Phase Separation (DIPS) technique. The scaffolds, with a vessel-like shape, were obtained by performing a DIPS process around a nylon fibre whose diameter was 700 μm. The fibre was first immersed into a 4% PLLA dioxane solution and subsequently immersed into a second bath containing distilled water. The covered fibre was then rinsed in order to remove the excess of dioxane and dried; finally the internal nylon fibre was pulled out so as to obtain a hollow biodegradable PLLA fiber. SEM analysis revealed that the scaffolds have a lumen of ca. 700 μm. The internal surface is homogeneous with micropores 1–2 μm large. Moreover, a cross section analysis showed an open structure across the thickness of the scaffold walls. A cell culture of endothelial cells was carried out into the as-prepared scaffolds. The result showed that cells are able to grow within the scaffolds and after 3 weeks they begin to form a “primordial” vessel-like structure.
  • Editor: Paris: Springer-Verlag
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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