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Computationally Modeling ncRNA-ncRNA Crosstalk

Xu, Juan ; Bai, Jing ; Xiao, Jun Ning, Shangwei ; Zhang, Yunpeng ; Xiao, Yun ; Li, Xia ; Xu, Juan

Non-Coding RNAs in Complex Diseases, 2018, Vol.1094, p.77-86 [Periódico revisado por pares]

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Título:
Computationally Modeling ncRNA-ncRNA Crosstalk
Autor: Xu, Juan ; Bai, Jing ; Xiao, Jun
Ning, Shangwei ; Zhang, Yunpeng ; Xiao, Yun ; Li, Xia ; Xu, Juan
Assuntos: Genomics ; Global and context specific ; miRNA-miRNA crosstalk ; miRNA-target interaction ; Phenomics
É parte de: Non-Coding RNAs in Complex Diseases, 2018, Vol.1094, p.77-86
Descrição: Our understanding of complex gene regulatory networks have been improved by the discovery of ncRNA-ncRNA crosstalk in normal and disease-specific physiological conditions. Previous studies have proposed numerous approaches for constructing ncRNA-ncRNA networks via ncRNA-mRNA regulation, functional information, or phenomics alone, or by combining heterogeneous data. Furthermore, it has been shown that ncRNA-ncRNA crosstalk can be rewired in different tissues or specific diseases. Therefore, it is necessary to integrate transcriptome data to construct context-specific ncRNA-ncRNA networks. In this chapter, we elucidated the commonly used ncRNA-ncRNA network modeling methods, and highlighted the need to integrate heterogeneous multi-mics data. Finally, we suggest future directions for studies of ncRNAs crosstalk. This comprehensive description and discussion elucidated in this chapter will provide constructive insights into ncRNA-ncRNA crosstalk.
Títulos relacionados: Advances in Experimental Medicine and Biology
Editor: Singapore: Springer Singapore Pte. Limited
Idioma: Inglês

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