skip to main content
Idioma:
Primo Search
Clear Search Box
Search in: Busca Geral
Busca Avançada
Busca por Índices
Tipo de recurso Mostra resultados com: Mostra resultados com: Índice

Synthesis, antifungal, antibacterial activity, and computational evaluations of some novel coumarin-1,2,4-triazole hybrid compounds

Karnaš, Maja ; Rastija, Vesna ; Vrandečić, Karolina ; Čosić, Jasenka ; Kanižai Šarić, Gabriella ; Agić, Dejan ; Šubarić, Domagoj ; Molnar, Maja

Journal of Taibah University for Science, 2024-12, Vol.18 (1) [Periódico revisado por pares]

Taylor & Francis Group

Texto completo disponível

Citações Citado por
  • Título:
    Synthesis, antifungal, antibacterial activity, and computational evaluations of some novel coumarin-1,2,4-triazole hybrid compounds
  • Autor: Karnaš, Maja ; Rastija, Vesna ; Vrandečić, Karolina ; Čosić, Jasenka ; Kanižai Šarić, Gabriella ; Agić, Dejan ; Šubarić, Domagoj ; Molnar, Maja
  • Assuntos: antimicrobial activity ; Coumarin-1,2,4-triazoles ; molecular docking ; plant protection ; QSAR ; sterol 14α-demethylase
  • É parte de: Journal of Taibah University for Science, 2024-12, Vol.18 (1)
  • Descrição: Effective plant pathogen control presents an important challenge. Pesticide resistance and associated health and environmental problems demonstrate the need for novel, safe active ingredients for plant protection. Since both coumarins and 1,2,4-triazoles show pesticidal activity, in this study, we evaluated the antimicrobial activity of coumarin-1,2,4-triazole hybrids against plant pathogenic fungi (Fusarium oxysporum, Fusarium culmorum, Macrophomina phaseolina and Sclerotinia sclerotiorum), bacterial plant pathogens (Pseudomonas syringae and Rhodococcus fascians), and beneficial bacteria (Bacillus mycoides and Bradyrhizobium japonicum). Coumarin-1,2,4-triazoles inhibited the growth of S. sclerotiorum and F. oxysporum, while no antibacterial effect on either pathogens or soil-beneficial bacteria was observed. A quantitative structure–activity relationship models for antifungal activities on S. sclerotiorum and F. oxysporum, developed using Dragon descriptors, can explain 79% and 77% of the compounds inhibitory activity, respectively. According to molecular docking, title compounds are potential sterol 14α-demethylase inhibitors, with 7-((5-mercapto-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)methoxy)-4-methyl-2H-chromen-2-one as the promising candidate for further research in plant protection.
  • Editor: Taylor & Francis Group
  • Idioma: Inglês
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.