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SAMHD1 phosphorylation and cytoplasmic relocalization after human cytomegalovirus infection limits its antiviral activity

De Meo, Simone ; Dell'Oste, Valentina ; Molfetta, Rosa ; Tassinari, Valentina ; Lotti, Lavinia Vittoria ; Vespa, Simone ; Pignoloni, Benedetta ; Covino, Daniela Angela ; Fantuzzi, Laura ; Bona, Roberta ; Zingoni, Alessandra ; Nardone, Ilaria ; Biolatti, Matteo ; Coscia, Alessandra ; Paolini, Rossella ; Benkirane, Monsef ; Edfors, Fredrik ; Sandalova, Tatyana ; Achour, Adnane ; Hiscott, John ; Landolfo, Santo ; Santoni, Angela ; Cerboni, Cristina Mocarski, Edward

PLoS pathogens, 2020-09, Vol.16 (9), p.e1008855-e1008855 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
SAMHD1 phosphorylation and cytoplasmic relocalization after human cytomegalovirus infection limits its antiviral activity
Autor: De Meo, Simone ; Dell'Oste, Valentina ; Molfetta, Rosa ; Tassinari, Valentina ; Lotti, Lavinia Vittoria ; Vespa, Simone ; Pignoloni, Benedetta ; Covino, Daniela Angela ; Fantuzzi, Laura ; Bona, Roberta ; Zingoni, Alessandra ; Nardone, Ilaria ; Biolatti, Matteo ; Coscia, Alessandra ; Paolini, Rossella ; Benkirane, Monsef ; Edfors, Fredrik ; Sandalova, Tatyana ; Achour, Adnane ; Hiscott, John ; Landolfo, Santo ; Santoni, Angela ; Cerboni, Cristina
Mocarski, Edward
Assuntos: Antiviral activity ; Antiviral agents ; Antiviral Agents - pharmacology ; Biology and Life Sciences ; Care and treatment ; Cell cycle ; Cellular proteins ; Cyclin-dependent kinase 2 ; Cyclin-dependent kinases ; Cyclin-Dependent Kinases - metabolism ; Cytomegalovirus ; Cytomegalovirus - genetics ; Cytomegalovirus - pathogenicity ; Cytomegalovirus infections ; Cytomegalovirus Infections - virology ; Cytoplasm ; Cytoplasm - metabolism ; Cytoplasm - virology ; Deactivation ; Deoxyribonucleic acid ; Development and progression ; DNA ; DNA viruses ; Fibroblasts ; Funding ; Gene expression ; Genetic aspects ; Health aspects ; Herpesviridae Infections - metabolism ; Hospitals ; Humans ; Hydrolase ; Immune system ; Inactivation ; Infection ; Infections ; Infectious diseases ; Investigations ; Kinases ; Laboratories ; Medicin och hälsovetenskap ; Medicine ; Medicine and Health Sciences ; Monomeric GTP-Binding Proteins - metabolism ; Mutation ; Pediatrics ; Pharmaceutical industry ; Phosphorylation ; Proteins ; Public health ; Research and Analysis Methods ; Ribonucleotide reductase ; SAM Domain and HD Domain-Containing Protein 1 - genetics ; Scientific equipment and supplies industry ; Viral infections ; Virus Replication - drug effects ; Viruses
É parte de: PLoS pathogens, 2020-09, Vol.16 (9), p.e1008855-e1008855
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The authors have declared that no competing interests exist.
Descrição: SAMHD1 is a host restriction factor that functions to restrict both retroviruses and DNA viruses, based on its nuclear deoxynucleotide triphosphate (dNTP) hydrolase activity that limits availability of intracellular dNTP pools. In the present study, we demonstrate that SAMHD1 expression was increased following human cytomegalovirus (HCMV) infection, with only a modest effect on infectious virus production. SAMHD1 was rapidly phosphorylated at residue T592 after infection by cellular cyclin-dependent kinases, especially Cdk2, and by the viral kinase pUL97, resulting in a significant fraction of phosho-SAMHD1 being relocalized to the cytoplasm of infected fibroblasts, in association with viral particles and dense bodies. Thus, our findings indicate that HCMV-dependent SAMHD1 cytoplasmic delocalization and inactivation may represent a potential novel mechanism of HCMV evasion from host antiviral restriction activities.
Editor: United States: Public Library of Science
Idioma: Inglês

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SAMHD1 phosphorylation and cytoplasmic relocalization after human cytomegalovirus infection limits its antiviral activity

United States: Public Library of Science

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