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How many patients enter endometrial cancer surgery with psychotropic medication prescriptions, and how many receive a new prescription perioperatively?

Sanjida, Saira ; Janda, Monika ; McPhail, Steven M. ; Kissane, David ; Couper, Jeremy ; Scott, James ; Obermair, Andreas

Gynecologic oncology, 2019-02, Vol.152 (2), p.339-345 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    How many patients enter endometrial cancer surgery with psychotropic medication prescriptions, and how many receive a new prescription perioperatively?
  • Autor: Sanjida, Saira ; Janda, Monika ; McPhail, Steven M. ; Kissane, David ; Couper, Jeremy ; Scott, James ; Obermair, Andreas
  • Assuntos: Adolescent ; Adult ; Aged ; Anti-Anxiety Agents - administration & dosage ; Antidepressant ; Antidepressive Agents - administration & dosage ; Anxiety and depression ; Anxiolytic ; Endometrial cancer ; Endometrial Neoplasms - psychology ; Endometrial Neoplasms - surgery ; Female ; Humans ; Middle Aged ; Perioperative Period - methods ; Perioperative Period - statistics & numerical data ; Prescription ; Psychotropic ; Psychotropic Drugs - administration & dosage ; Socioeconomic Factors ; Young Adult
  • É parte de: Gynecologic oncology, 2019-02, Vol.152 (2), p.339-345
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-News-2
    ObjectType-Feature-3
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  • Descrição: Psychotropic medications including antidepressants and anxiolytics are used to treat anxiety and depression in cancer patients; however, little is known about the prescription practices in endometrial cancer. This study aimed to determine the prevalence, type, dose, frequency and timing of psychotropic medications prescribed to endometrial cancer patients. A secondary aim was to study sociodemographic and clinical characteristics associated with receiving a psychotropic medication prescription. Secondary data analysis of an international, multicentre, prospective randomised controlled trial was conducted. Patients aged >18 years diagnosed with Stage I endometrial cancer were included. Logistic regression models were fitted to estimate the association of receiving psychotropic medications with patient's socio-demographic and clinical characteristics. The overall prevalence of patients prescribed one or more psychotropic medications was 16.8% (n = 121/719) comprising antidepressants (12.6%, n = 91/719) and anxiolytics (5.8%, n = 42/719). The majority of patients (78.1%, n = 71/91) were already receiving antidepressants before cancer diagnosis, the remaining medications were newly prescribed perioperatively (21.9%, n = 20/91). Patients of younger age (18–50 years, OR (Odds Ratio): 2.61), who had hypertension (OR: 0.61), history of a previous cancer (OR: 1.96), and ≥2 comorbidities (2–3, OR: 2.97; 4–5, OR: 7.85; ≥6, OR: 9.13) were significantly (p < 0.05) more likely to receive a prescription of psychotropic medications. While one in eight patients already had psychotropic medications prescribed before surgery for early stage endometrial cancer, only few women received a new prescription after surgery. The overall prescription rates were similar to other patients with cancer, but higher than those observed in the general population, likely reflecting the comorbidity burden of patients who develop endometrial cancer. Qualitative data could be used in future research to explore the psychological and quality of life impacts of endometrial cancer. •One in eight patients already had psychotropic medications prescribed before surgery for early stage endometrial cancer.•Previous history of cancers increases the odds for psychotropic medications is a novel finding of this study.•Multiple comorbidities are associated with increasing prevalence of prescription of psychotropic medications.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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