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Trophoblast L-Selectin-Mediated Adhesion at the Maternal-Fetal Interface

Genbacev, Olga D. ; Prakobphol, Akraporn ; Foulk, Russell A. ; Krtolica, Ana R. ; Ilic, Dusko ; Singer, Mark S. ; Yang, Zhi-Qiang ; Kiessling, Laura L. ; Rosen, Steven D. ; Fisher, Susan J.

Science (American Association for the Advancement of Science), 2003-01, Vol.299 (5605), p.405-408 [Periódico revisado por pares]

Washington, DC: American Association for the Advancement of Science

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Título:
Trophoblast L-Selectin-Mediated Adhesion at the Maternal-Fetal Interface
Autor: Genbacev, Olga D. ; Prakobphol, Akraporn ; Foulk, Russell A. ; Krtolica, Ana R. ; Ilic, Dusko ; Singer, Mark S. ; Yang, Zhi-Qiang ; Kiessling, Laura L. ; Rosen, Steven D. ; Fisher, Susan J.
Assuntos: Animals ; Antibodies ; Biological and medical sciences ; Biopsies ; Blastocyst - physiology ; Blasts ; Cell Adhesion ; Cells ; Cells, Cultured ; Cytology ; Embryo Implantation ; Embryos ; Endometrium - cytology ; Endometrium - metabolism ; Endometrium - physiology ; Epithelial Cells - metabolism ; Epithelium ; Female ; Follicular Phase ; Fundamental and applied biological sciences. Psychology ; Humans ; Immunoblotting ; Jurkat Cells ; L-Selectin - immunology ; L-Selectin - metabolism ; Leukocytes ; Ligands ; Luteal Phase ; Mammalian female genital system ; Mice ; Microspheres ; Morphology. Physiology ; Oligosaccharides - metabolism ; Organ Culture Techniques ; Pregnancy ; Prenatal development ; Reproduction ; Selectins ; Trophoblast ; Trophoblasts ; Trophoblasts - metabolism ; Trophoblasts - physiology ; Up-Regulation ; Uterus ; Vertebrates: reproduction
É parte de: Science (American Association for the Advancement of Science), 2003-01, Vol.299 (5605), p.405-408
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Descrição: Trophoblast adhesion to the uterine wall is the requisite first step of implantation and, subsequently, placentation. At the maternal-fetal interface, we investigated the expression of selectin adhesion systems that enable leukocyte capture from the bloodstream. On the maternal side, human uterine epithelial cells up-regulated selectin oligosaccharide-based ligands during the window of receptivity. On the fetal side, human trophoblasts expressed L-selectin. This ligand-receptor system was functional, because beads coated with the selectin ligand 6-sulfo sLexbound to trophoblasts, and trophoblasts bound to ligand-expressing uterine luminal epithelium in tissue sections. These results suggest that trophoblast L-selectin mediates interactions with the uterus and that this adhesion mechanism may be critical to establishing human pregnancy.
Editor: Washington, DC: American Association for the Advancement of Science
Idioma: Inglês

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Trophoblast L-Selectin-Mediated Adhesion at the Maternal-Fetal Interface

Genbacev, Olga D. ; Prakobphol, Akraporn ; Foulk, Russell A. ; Krtolica, Ana R. ; Ilic, Dusko ; Singer, Mark S. ; Yang, Zhi-Qiang ; Kiessling, Laura L. ; Rosen, Steven D. ; Fisher, Susan J.

Washington, DC: American Association for the Advancement of Science

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