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Clinical Features, Outcomes, and Molecular Characteristics of Community- and Health Care-Associated Staphylococcus lugdunensis Infections

Yeh, Chun-Fu ; Chang, Shih-Cheng ; Cheng, Chun-Wen ; Lin, Jung-Fu ; Liu, Tsui-Ping ; Lu, Jang-Jih Patel, R.

Journal of clinical microbiology, 2016-08, Vol.54 (8), p.2051-2057 [Periódico revisado por pares]

United States: American Society for Microbiology

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Título:
Clinical Features, Outcomes, and Molecular Characteristics of Community- and Health Care-Associated Staphylococcus lugdunensis Infections
Autor: Yeh, Chun-Fu ; Chang, Shih-Cheng ; Cheng, Chun-Wen ; Lin, Jung-Fu ; Liu, Tsui-Ping ; Lu, Jang-Jih
Patel, R.
Assuntos: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents - pharmacology ; Bacteriology ; Child ; Child, Preschool ; Community-Acquired Infections - microbiology ; Community-Acquired Infections - pathology ; Cross Infection - microbiology ; Cross Infection - pathology ; Drug Resistance, Bacterial ; Female ; Genotype ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Molecular Typing ; Retrospective Studies ; Staphylococcal Infections - microbiology ; Staphylococcal Infections - pathology ; Staphylococcus lugdunensis ; Staphylococcus lugdunensis - classification ; Staphylococcus lugdunensis - genetics ; Staphylococcus lugdunensis - isolation & purification ; Survival Analysis ; Treatment Outcome ; Young Adult
É parte de: Journal of clinical microbiology, 2016-08, Vol.54 (8), p.2051-2057
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Citation Yeh C-F, Chang S-C, Cheng C-W, Lin J-F, Liu T-P, Lu J-J. 2016. Clinical features, outcomes, and molecular characteristics of community- and health care-associated Staphylococcus lugdunensis infections. J Clin Microbiol 54:2051–2057. doi:10.1128/JCM.00847-16.
Descrição: Staphylococcus lugdunensis is a major cause of aggressive endocarditis, but it is also responsible for a broad spectrum of infections. The differences in clinical and molecular characteristics between community-associated (CA) and health care-associated (HA) S. lugdunensis infections have remained unclear. We performed a retrospective study of S. lugdunensis infections between 2003 and 2014 to compare the clinical and molecular characteristics of CA and HA isolates. We collected 129 S. lugdunensis isolates in total: 81 (62.8%) HA isolates and 48 (37.2%) CA isolates. HA infections were more frequent than CA infections in children (16.0% versus 4.2%, respectively; P = 0.041) and the elderly (38.3% versus 14.6%, respectively; P = 0.004). The CA isolates were more likely to cause skin and soft tissue infections (85.4% versus 19.8%, respectively; P < 0.001). HA isolates were more frequently responsible for bacteremia of unknown origin (34.6% versus 4.2%, respectively; P < 0.001) and for catheter-related bacteremia (12.3% versus 0%, respectively; P = 0.011) than CA isolates. Fourteen-day mortality was higher for HA infections than for CA infections (11.1% versus 0%, respectively). A higher proportion of the HA isolates than of the CA isolates were resistant to penicillin (76.5% versus 52.1%, respectively; P = 0.004) and oxacillin (32.1% versus 2.1%, respectively; P < 0.001). Two major clonal complexes (CC1 and CC3) were identified. Sequence type 41 (ST41) was the most common sequence type identified (29.5%). The proportion of ST38 isolates was higher for HA than for CA infections (33.3% versus 12.5%, respectively; P = 0.009). These isolates were of staphylococcal cassette chromosome mec element (SCCmec)type IV, V, or Vt. HA and CA S. lugdunensis infections differ in terms of their clinical features, outcome, antibiotic susceptibilities, and molecular characteristics.
Editor: United States: American Society for Microbiology
Idioma: Inglês

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Clinical Features, Outcomes, and Molecular Characteristics of Community- and Health Care-Associated Staphylococcus lugdunensis Infections

Yeh, Chun-Fu ; Chang, Shih-Cheng ; Cheng, Chun-Wen ; Lin, Jung-Fu ; Liu, Tsui-Ping ; Lu, Jang-Jih Patel, R.

United States: American Society for Microbiology

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