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Dissecting hair breakage in alopecia areata: the central role of dysregulated cysteine homeostasis

Xu, Wen ; Xie, Bo ; Wei, Dongfan ; Song, Xiuzu

Amino acids, 2024-05, Vol.56 (1), p.36-36, Article 36 [Periódico revisado por pares]

Vienna: Springer Vienna

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Título:
Dissecting hair breakage in alopecia areata: the central role of dysregulated cysteine homeostasis
Autor: Xu, Wen ; Xie, Bo ; Wei, Dongfan ; Song, Xiuzu
Assuntos: Alopecia ; Alopecia Areata - metabolism ; Alopecia Areata - pathology ; Alopecia Areata - physiopathology ; Amino acids ; Analytical Chemistry ; Animals ; Autophagy ; Baldness ; Biochemical Engineering ; Biochemistry ; Biomedical and Life Sciences ; Chemical bonds ; Cysteine ; Cysteine - metabolism ; Dermatology ; Ferroptosis ; Follicles ; Hair ; Hair - metabolism ; Hair loss ; Homeostasis ; Homocysteine ; Hospitals ; Humans ; Keratin ; Life Sciences ; Medical innovations ; Metabolism ; Metabolites ; Mutation ; Neurobiology ; Pathogenesis ; Pathophysiology ; Proteins ; Proteomics ; Review ; Review Article
É parte de: Amino acids, 2024-05, Vol.56 (1), p.36-36, Article 36
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Handling editor: A. Galdino.
Descrição: In the initial stages of Alopecia Areata (AA), the predominance of hair breakage or exclamation mark hairs serves as vital indicators of disease activity. These signs are non-invasive and are commonly employed in dermatoscopic examinations. Despite their clinical salience, the underlying etiology precipitating this hair breakage remains largely uncharted territory. Our exhaustive review of the existing literature points to a pivotal role for cysteine—a key amino acid central to hair growth—in these mechanisms. This review will probe and deliberate upon the implications of aberrant cysteine metabolism in the pathogenesis of AA. It will examine the potential intersections of cysteine metabolism with autophagy, ferroptosis, immunity, and psychiatric manifestations associated with AA. Such exploration could illuminate new facets of the disease's pathophysiology, potentially paving the way for innovative therapeutic strategies.
Editor: Vienna: Springer Vienna
Idioma: Inglês

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Dissecting hair breakage in alopecia areata: the central role of dysregulated cysteine homeostasis

Xu, Wen ; Xie, Bo ; Wei, Dongfan ; Song, Xiuzu

Vienna: Springer Vienna

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