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Clinical and molecular epidemiology of haemophilus influenzae causing invasive disease in adult patients

Puig, Carmen ; Grau, Imma ; Marti, Sara ; Tubau, Fe ; Calatayud, Laura ; Pallares, Roman ; Liñares, Josefina ; Ardanuy, Carmen Trotter, Caroline L.

PloS one, 2014-11, Vol.9 (11), p.e112711-e112711 [Periódico revisado por pares]

United States: Public Library of Science

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Clinical and molecular epidemiology of haemophilus influenzae causing invasive disease in adult patients
Autor: Puig, Carmen ; Grau, Imma ; Marti, Sara ; Tubau, Fe ; Calatayud, Laura ; Pallares, Roman ; Liñares, Josefina ; Ardanuy, Carmen
Trotter, Caroline L.
Assuntos: Adult ; Adults ; Aged ; Aged, 80 and over ; Amino acid sequence ; Ampicillin ; Anti-Bacterial Agents - pharmacology ; Antibiotics ; Antiinfectives and antibacterials ; Antimicrobial agents ; Antimicrobial resistance ; Biology and Life Sciences ; Chronic obstructive lung disease ; Chronic obstructive pulmonary disease ; Comorbidity ; Cotrimoxazole ; Diabetes mellitus ; Diabetes Mellitus - epidemiology ; Diabetes therapy ; Drug resistance ; Epidemiologia molecular ; Epidemiology ; Female ; Genes ; Genetic diversity ; Genotype ; Genotyping ; Geriatrics ; Haemophilus Infections - epidemiology ; Haemophilus Infections - microbiology ; Haemophilus influenzae ; Haemophilus influenzae - classification ; Haemophilus influenzae - drug effects ; Haemophilus influenzae - genetics ; Hemophilus infections ; Humans ; Immunization ; Immunosuppressive agents ; Infection ; Infections ; Infectious diseases ; Laboratories ; Lung diseases, Obstructive ; Malalties de l'aparell respiratori ; Male ; Malignancy ; Medicine and Health Sciences ; Microbial Sensitivity Tests ; Middle Aged ; Molecular Epidemiology ; Molecular Typing - methods ; Mortality ; Mutation ; Older people ; Patients ; Pulmonary Disease, Chronic Obstructive - epidemiology ; Respiratory organs diseases ; Serotyping ; Serotyping - methods ; Spain - epidemiology ; Strains (organisms) ; Vaccines ; Young Adult
É parte de: PloS one, 2014-11, Vol.9 (11), p.e112711-e112711
Notas: ObjectType-Article-1
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Conceived and designed the experiments: CP SM CA JL RP. Performed the experiments: CP SM IG. Analyzed the data: CP SM CA JL IG RP. Contributed reagents/materials/analysis tools: FT LC IG RP. Contributed to the writing of the manuscript: CP SM CA JL RP.
Competing Interests: The authors have declared that no competing interests exist.
Descrição: The epidemiology of invasive Haemophilus influenzae (Hi) has changed since the introduction of the Hi type b (Hib) vaccine. The aim of this study was to analyze the clinical and molecular epidemiology of Hi invasive disease in adults. Clinical data of the 82 patients with Hi invasive infections were analyzed. Antimicrobial susceptibility, serotyping, and genotyping were studied (2008-2013). Men accounted for 63.4% of patients (whose mean age was 64.3 years). The most frequent comorbidities were immunosuppressive therapy (34.1%), malignancy (31.7%), diabetes, and COPD (both 22%). The 30-day mortality rate was 20.7%. The majority of the strains (84.3%) were nontypeable (NTHi) and serotype f was the most prevalent serotype in the capsulated strains. The highest antimicrobial resistance was for cotrimoxazole (27.1%) and ampicillin (14.3%). Twenty-three isolates (32.9%) had amino acid changes in the PBP3 involved in resistance. Capsulated strains were clonal and belonged to clonal complexes 6 (serotype b), 124 (serotype f), and 18 (serotype e), whereas NTHi were genetically diverse. Invasive Hi disease occurred mainly in elderly and those with underlying conditions, and it was associated with a high mortality rate. NTHi were the most common cause of invasive disease and showed high genetic diversity.
Editor: United States: Public Library of Science
Idioma: Inglês

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Clinical and molecular epidemiology of haemophilus influenzae causing invasive disease in adult patients

Puig, Carmen ; Grau, Imma ; Marti, Sara ; Tubau, Fe ; Calatayud, Laura ; Pallares, Roman ; Liñares, Josefina ; Ardanuy, Carmen Trotter, Caroline L.

United States: Public Library of Science

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