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Prostaglandins E sub(1) and E sub(2) Interact With Prostaglandin F sub(2 alpha ) to Regulate Initiation of DNA Replication and Cell Division in Swiss 3T3 Cells

Otto, A M ; Nilsen-Hamilton, M ; Boss, B D ; Ulrich, MO ; Jimenez de Asua, L

Proceedings of the National Academy of Sciences - PNAS, 1982-01, Vol.79 (16), p.4992-4996 [Periódico revisado por pares]

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Título:
Prostaglandins E sub(1) and E sub(2) Interact With Prostaglandin F sub(2 alpha ) to Regulate Initiation of DNA Replication and Cell Division in Swiss 3T3 Cells
Autor: Otto, A M ; Nilsen-Hamilton, M ; Boss, B D ; Ulrich, MO ; Jimenez de Asua, L
É parte de: Proceedings of the National Academy of Sciences - PNAS, 1982-01, Vol.79 (16), p.4992-4996
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Feature-1
Descrição: Prostaglandin (PG) E sub(1) or E sub(2) added at 2-1,000 ng/ml to quiescent cultures of Swiss 3T3 cells synergistically enhanced the rate of initiation of DNA replication stimulated by PGF sub(2 alpha ) alone or with insulin. Neither PGD sub(2) nor PGF sub(1 alpha ) had any effect with PGF sub(2 alpha ). An increase in the rate of entry into S phase also occurred when PGE sub(1) or PGE sub(2) was added 8 or 15 hr after addition of PGF sub(2 alpha ). However, adding PGE sub(1) and PGE sub(2) together with PGF sub(2 alpha ) did not further enhance the synergistic effect observed with PGE sub(1) or PGE sub(2) separately. The synergistic effect was also observed in stimulation of 2-deoxyglucose uptake but not in early changes of intracellular levels of cAMP. These results may be relevant in understanding the control of fibroblastic proliferation in wound healing and may provide an alternative mechanism for oncogenic transformation.
Idioma: Inglês

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