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The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia

Franco, Rendrik F. ; Simões, Belinda P. ; Tone, Luiz G. ; Gabellini, Sérgio M. ; Zago, Marco A. ; Falcão, Roberto P.

British journal of haematology, 2001-12, Vol.115 (3), p.616-618 [Periódico revisado por pares]

Oxford, UK: Blackwell Science Ltd

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Título:
The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia
Autor: Franco, Rendrik F. ; Simões, Belinda P. ; Tone, Luiz G. ; Gabellini, Sérgio M. ; Zago, Marco A. ; Falcão, Roberto P.
Assuntos: acute lymphocytic leukaemia ; Adolescent ; Biological and medical sciences ; Burkitt Lymphoma - genetics ; Case-Control Studies ; Child ; Child, Preschool ; Confidence Intervals ; Female ; folate metabolism ; Germ-Line Mutation ; Hematologic and hematopoietic diseases ; Hematology ; Heterozygote ; Homozygote ; Humans ; Infant ; Leukemia-Lymphoma, Adult T-Cell - genetics ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; Methylenetetrahydrofolate Reductase (NADPH2) ; MTHFR ; Odds Ratio ; Oxidoreductases Acting on CH-NH Group Donors - genetics ; Polymorphism, Genetic ; polymorphisms ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Prevalence ; Risk ; risk factor
É parte de: British journal of haematology, 2001-12, Vol.115 (3), p.616-618
Notas: ObjectType-Article-1
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Descrição: We have determined the prevalence of methylenetetrahydrofolate reductase (MTHFR) mutations C677T and A1298C in 71 children ( 15 years) with acute lymphoblastic leukaemia (ALL) and in 71 control subjects. Odds ratio (OR) for ALL linked to MTHFR C677T was 0·4 (95% CI 0·2–0·8); for heterozygotes it was 0·5 (95% CI 0·2–0·9) and for homozygotes it was 0·3 (95%CI 0·09–0·8). MTHFR A1298C yielded an overall OR for ALL of 1·3 (95% CI: 0·7–2·6); for heterozygotes it was 1·3 (95% CI: 0·7–7·6) and for homozygotes it was 2·8 (95% CI 0·5–15·6). In conclusion, MTHFR C677T was linked to a significant 2·4‐fold decreased risk of developing childhood ALL, whereas MTHFR A1298C did not significantly affect the risk of ALL in our population.
Editor: Oxford, UK: Blackwell Science Ltd
Idioma: Inglês

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The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia

Franco, Rendrik F. ; Simões, Belinda P. ; Tone, Luiz G. ; Gabellini, Sérgio M. ; Zago, Marco A. ; Falcão, Roberto P.

Oxford, UK: Blackwell Science Ltd

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