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CD4+ T cells defined by their V[beta] T cell receptor expression are associated with immunoregulatory profiles and lesion size in human leishmaniasis

Keesen, T S L ; Antonelli, L R V ; Faria, D R ; Guimaraes, L H ; Bacellar, O ; Carvalho, E M ; Dutra, W O ; Gollob, K J

Clinical and experimental immunology, 2011-09, Vol.165 (3), p.338 [Periódico revisado por pares]

Oxford: Oxford University Press

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  • Título:
    CD4+ T cells defined by their V[beta] T cell receptor expression are associated with immunoregulatory profiles and lesion size in human leishmaniasis
  • Autor: Keesen, T S L ; Antonelli, L R V ; Faria, D R ; Guimaraes, L H ; Bacellar, O ; Carvalho, E M ; Dutra, W O ; Gollob, K J
  • É parte de: Clinical and experimental immunology, 2011-09, Vol.165 (3), p.338
  • Descrição: Summary Leishmaniasis is caused by infection with the protozoan parasite, Leishmania, that parasitizes human cells, and the cellular immune response is essential for controlling infection. In order to measure the host T cell response to Leishmania infection, we have measured the expansion, activation state and functional potential of specific T cells as identified by their T cell receptor V[beta] region expression. In a group of cutaneous leishmaniasis (CL) patients, we evaluated these characteristics in nine different T cell subpopulations as identified by their V[beta] region expression, before and after specific Leishmania antigen stimulation. Our results show: (1) an increase in CD4+ T cells expressing V[beta] 5·2 and V[beta] 24 in CL compared to controls; (2) a Leishmania antigen-induced increase in CD4+ T cells expressing V[beta] 5·2, 11, 12 and 17; (3) a profile of previous activation of CD4+ V[beta] 5·2-, 11- and 24-positive T cells, with higher expression of CD45RO, HLA-DR, interferon-[gamma], tumour necrosis factor-[alpha] and interleukin-10 compared to other V[beta]-expressing subpopulations; (4) a positive correlation between higher frequencies of CD4+V[beta]5·2+ T cells and larger lesions; and (5) biased homing of CD4+ T cells expressing V[beta] 5·2 to the lesion site. Given that CL disease involves a level of pathology (ulcerated lesions) and is often followed by long-lived protection and cure, the identification of specific subpopulations active in this form of disease could allow for the discovery of immunodominant Leishmania antigens important for triggering efficient host responses against the parasite, or identify cell populations most involved in pathology. [PUBLICATION ABSTRACT]
  • Editor: Oxford: Oxford University Press
  • Idioma: Inglês
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