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1,3,4-Thiadiazole derivatives of R-(+)-limonene benzaldehyde-thiosemicarbazones cause death in Trypanosoma cruzi through oxidative stress

Martins, Solange C. ; Lazarin-Bidóia, Danielle ; Desoti, Vânia C. ; Falzirolli, Hugo ; da Silva, Cleuza C. ; Ueda-Nakamura, Tania ; Silva, Sueli de O. ; Nakamura, Celso V.

Microbes and infection, 2016-12, Vol.18 (12), p.787-797 [Periódico revisado por pares]

France: Elsevier Masson SAS

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Título:
1,3,4-Thiadiazole derivatives of R-(+)-limonene benzaldehyde-thiosemicarbazones cause death in Trypanosoma cruzi through oxidative stress
Autor: Martins, Solange C. ; Lazarin-Bidóia, Danielle ; Desoti, Vânia C. ; Falzirolli, Hugo ; da Silva, Cleuza C. ; Ueda-Nakamura, Tania ; Silva, Sueli de O. ; Nakamura, Celso V.
Assuntos: Animals ; Antiprotozoal Agents - chemistry ; Antiprotozoal Agents - pharmacology ; Benzaldehydes - chemistry ; Benzaldehydes - pharmacology ; Cell death ; Chagas Disease - drug therapy ; Chagas Disease - parasitology ; Chagas' disease ; Cyclohexenes - chemistry ; Cyclohexenes - pharmacology ; Disease Models, Animal ; Female ; Humans ; Mice, Inbred BALB C ; Mitochondrial dysfunction ; Molecular Structure ; Oxidative Stress ; Parasite Load ; Parasitemia - drug therapy ; Parasitemia - parasitology ; Terpenes - chemistry ; Terpenes - pharmacology ; Thiadiazole ; Thiadiazoles - chemistry ; Thiadiazoles - pharmacology ; Thiosemicarbazones - chemistry ; Thiosemicarbazones - pharmacology ; Treatment Outcome ; Trypanosoma cruzi - drug effects ; Trypanosoma cruzi - growth & development ; Trypanosoma cruzi - physiology ; Trypanosoma cruzi - ultrastructure
É parte de: Microbes and infection, 2016-12, Vol.18 (12), p.787-797
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SourceType-Scholarly Journals-1
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Descrição: This work evaluated the in vitro and in vivo activity of TDZ 2 on Trypanosoma cruzi amastigotes and determined the possible mechanism of action of this compound on T. cruzi death. TDZ 2 inhibited T. cruzi proliferation in vitro and had low haemolytic potential. It also induced morphological and ultrastructural alterations. We observed a reduction of cell volume, the depolarization of the mitochondrial membrane, an increase in ROS production, lipoperoxidation of the cell membrane, lipid bodies formation and production of nitric oxide, a decrease in reduced thiols levels and, presence of autophagic vacuoles. The in vivo study found a reduction of parasitemia in animals treated with TDZ 2 alone or combined with benznidazole. Altogether, the alterations induced by TDZ 2 point to an oxidative stress condition that lead to T. cruzi cell death.
Editor: France: Elsevier Masson SAS
Idioma: Inglês

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1,3,4-Thiadiazole derivatives of R-(+)-limonene benzaldehyde-thiosemicarbazones cause death in Trypanosoma cruzi through oxidative stress

Martins, Solange C. ; Lazarin-Bidóia, Danielle ; Desoti, Vânia C. ; Falzirolli, Hugo ; da Silva, Cleuza C. ; Ueda-Nakamura, Tania ; Silva, Sueli de O. ; Nakamura, Celso V.

France: Elsevier Masson SAS

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