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Extended effect of chronic social defeat stress in childhood on behaviors in adulthood

Kovalenko, Irina L ; Galyamina, Anna G ; Smagin, Dmitry A ; Michurina, Tatyana V ; Kudryavtseva, Natalia N ; Enikolopov, Grigori Trezza, Viviana

PloS one, 2014-03, Vol.9 (3), p.e91762-e91762 [Revista revisada por pares]

United States: Public Library of Science

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Título:
Extended effect of chronic social defeat stress in childhood on behaviors in adulthood
Autor: Kovalenko, Irina L ; Galyamina, Anna G ; Smagin, Dmitry A ; Michurina, Tatyana V ; Kudryavtseva, Natalia N ; Enikolopov, Grigori
Trezza, Viviana
Materias: Adolescence ; Adolescents ; Aggression - psychology ; Aggressiveness ; Analysis ; Animal behavior ; Animal cognition ; Animals ; Anxiety ; Anxiety - psychology ; Autism ; Behavior ; Behavior, Animal ; Biology and Life Sciences ; Brain ; Cages ; Cellular biology ; Child development ; Children ; Chronic Disease ; Dentate gyrus ; Development and progression ; Emotions ; Exposure ; Females ; Genetics ; Hippocampus - cytology ; Laboratories ; Levels ; Male ; Males ; Maze Learning ; Medicine and Health Sciences ; Memory ; Mice ; Mice, Inbred C57BL ; Neurogenesis ; Neurosciences ; Physics ; Research and Analysis Methods ; Rodents ; Social aspects ; Social Behavior ; Social Environment ; Social factors ; Social interactions ; Stress ; Stress, Psychological - physiopathology ; Stress, Psychological - psychology ; Stresses ; Studies ; Teenagers ; Territory
Es parte de: PloS one, 2014-03, Vol.9 (3), p.e91762-e91762
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: NNK ILK GE. Performed the experiments: ILK AGG DAS TVM. Analyzed the data: NNK ILK AGG GE. Contributed reagents/materials/analysis tools: NNK GE. Wrote the paper: NNK GE ILK.
Descripción: Individuals exposed to social stress in childhood are more predisposed to developing psychoemotional disorders in adulthood. Here we use an animal model to determine the influence of hostile social environment in adolescence on behavior during adult life. One-month-old adolescent male mice were placed for 2 weeks in a common cage with an adult aggressive male. Animals were separated by a transparent perforated partition, but the adolescent male was exposed daily to short attacks from the adult male. After exposure to social stress, some of the adolescent mice were placed for 3 weeks in comfortable conditions. Following this rest period, stressed young males and adult males were studied in a range of behavioral tests to evaluate the levels of anxiety, depressiveness, and communicativeness with an unfamiliar partner. In addition, adult mice exposed to social stress in adolescence were engaged in agonistic interactions. We found that 2 weeks of social stress result in a decrease of communicativeness in the home cage and diminished social interactions on the novel territory. Stressed adolescents demonstrated a high level of anxiety in the elevated plus-maze test and helplessness in the Porsolt test. Furthermore, the number of dividing (BrdU-positive) cells in the subgranular zone of the dentate gyrus was significantly lower in stressed adolescents. After 3 weeks of rest, most behavioral characteristics in different tests, as well as the number of BrdU-positive cells in the hippocampus, did not differ from those of the respective control mice. However, the level of anxiety remained high in adult males exposed to chronic social stress in childhood. Furthermore, these males were more aggressive in the agonistic interactions. Thus, hostile social environment in adolescence disturbs psychoemotional state and social behaviors of animals in adult life.
Editor: United States: Public Library of Science
Idioma: Inglés

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Extended effect of chronic social defeat stress in childhood on behaviors in adulthood

Kovalenko, Irina L ; Galyamina, Anna G ; Smagin, Dmitry A ; Michurina, Tatyana V ; Kudryavtseva, Natalia N ; Enikolopov, Grigori Trezza, Viviana

United States: Public Library of Science

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