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A Randomized Trial of Colchicine for Acute Pericarditis

Imazio, Massimo ; Brucato, Antonio ; Cemin, Roberto ; Ferrua, Stefania ; Maggiolini, Stefano ; Beqaraj, Federico ; Demarie, Daniela ; Forno, Davide ; Ferro, Silvia ; Maestroni, Silvia ; Belli, Riccardo ; Trinchero, Rita ; Spodick, David H ; Adler, Yehuda

The New England journal of medicine, 2013-10, Vol.369 (16), p.1522-1528 [Periódico revisado por pares]

Waltham, MA: Massachusetts Medical Society

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Título:
A Randomized Trial of Colchicine for Acute Pericarditis
Autor: Imazio, Massimo ; Brucato, Antonio ; Cemin, Roberto ; Ferrua, Stefania ; Maggiolini, Stefano ; Beqaraj, Federico ; Demarie, Daniela ; Forno, Davide ; Ferro, Silvia ; Maestroni, Silvia ; Belli, Riccardo ; Trinchero, Rita ; Spodick, David H ; Adler, Yehuda
Assuntos: Acute Disease ; Adolescent ; Adult ; Aged ; Anti-Inflammatory Agents - adverse effects ; Anti-Inflammatory Agents - therapeutic use ; Aspirin ; Aspirin - therapeutic use ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Cardiology. Vascular system ; Colchicine ; Colchicine - adverse effects ; Colchicine - therapeutic use ; Diseases of the pericardium ; Double-Blind Method ; Drug dosages ; Drug therapy ; Drug Therapy, Combination ; Evidence-based medicine ; Female ; General aspects ; Heart ; Humans ; Ibuprofen ; Ibuprofen - therapeutic use ; Kaplan-Meier Estimate ; Male ; Medical research ; Medical sciences ; Middle Aged ; Patients ; Pericarditis ; Pericarditis - drug therapy ; Pharmacology. Drug treatments ; Prednisone - therapeutic use ; Remission ; Secondary Prevention ; Young Adult
É parte de: The New England journal of medicine, 2013-10, Vol.369 (16), p.1522-1528
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-News-2
ObjectType-Feature-3
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Descrição: In a randomized trial, patients with acute pericarditis were assigned to either colchicine or placebo in addition to conventional antiinflammatory therapy. Colchicine significantly reduced the incidence of incessant or recurrent pericarditis. Colchicine has been used for centuries to treat and prevent gouty attacks 1 and more recently has been recommended to treat and prevent serositis in patients with familial Mediterranean fever and recurrent pericarditis. 2 , 3 Preliminary data from nonrandomized trials have also supported the use of colchicine for the treatment and prevention of acute pericarditis. 4 In a single-center, open-label, randomized trial, called the Colchicine for Acute Pericarditis (COPE) study, the addition of colchicine to conventional therapy with either aspirin or glucocorticoids halved the recurrence rate after an initial attack of acute pericarditis. 5 Our study, called the Investigation on Colchicine for Acute Pericarditis . . .
Editor: Waltham, MA: Massachusetts Medical Society
Idioma: Inglês

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A Randomized Trial of Colchicine for Acute Pericarditis

Imazio, Massimo ; Brucato, Antonio ; Cemin, Roberto ; Ferrua, Stefania ; Maggiolini, Stefano ; Beqaraj, Federico ; Demarie, Daniela ; Forno, Davide ; Ferro, Silvia ; Maestroni, Silvia ; Belli, Riccardo ; Trinchero, Rita ; Spodick, David H ; Adler, Yehuda

Waltham, MA: Massachusetts Medical Society

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