Idioma:

Corneal Stroma Enhancement With Decellularized Stromal Laminas With or Without Stem Cell Recellularization for Advanced Keratoconus

Alió del Barrio, Jorge L. ; El Zarif, Mona ; Azaar, Albert ; Makdissy, Nehman ; Khalil, Charbel ; Harb, Walid ; El Achkar, Ibrahim ; Jawad, Ziad Abdul ; de Miguel, María P. ; Alió, Jorge L.

American journal of ophthalmology, 2018-02, Vol.186, p.47-58 [Periódico revisado por pares]

United States: Elsevier Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Corneal Stroma Enhancement With Decellularized Stromal Laminas With or Without Stem Cell Recellularization for Advanced Keratoconus
Autor: Alió del Barrio, Jorge L. ; El Zarif, Mona ; Azaar, Albert ; Makdissy, Nehman ; Khalil, Charbel ; Harb, Walid ; El Achkar, Ibrahim ; Jawad, Ziad Abdul ; de Miguel, María P. ; Alió, Jorge L.
Assuntos: Adult ; Astigmatism ; Cataracts ; Cell cycle ; Cells, Cultured ; Collagen ; Consent ; Cornea ; Corneal Pachymetry ; Corneal Stroma - pathology ; Corneal Stroma - transplantation ; Corneal Topography - methods ; Corneal Transplantation - methods ; Extracellular matrix ; Female ; Flow cytometry ; Follow-Up Studies ; Hepatitis ; Humans ; Keratoconus - pathology ; Keratoconus - surgery ; Male ; Middle Aged ; Ophthalmology ; Patients ; Prospective Studies ; Refraction, Ocular ; Scars ; Severity of Illness Index ; Stem Cell Transplantation - methods ; Stem cells ; Stem Cells - cytology ; Time Factors ; Tissue engineering ; Tomography, Optical Coherence ; Transplantation, Autologous ; Transplants & implants ; Treatment Outcome ; Visual Acuity ; Young Adult
É parte de: American journal of ophthalmology, 2018-02, Vol.186, p.47-58
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-News-3
content type line 23
Descrição: This phase 1 study seeks to preliminarily evaluate the safety and efficacy of decellularized human corneal stromal lamina transplantation with or without autologous adipose-derived adult stem cell recellularization within the corneal stroma of patients with advanced keratoconus. Phase 1 clinical trial. Femtosecond-assisted 120-μm thickness and 9-mm diameter laminas were obtained from the anterior stroma of human donor corneas and decellularized with a sodium dodecyl sulfate solution. Autologous adipose-derived adult stem cells were obtained by elective liposuction and cultured onto both sides of the lamina. Five patients received the decellularized lamina alone and 4 patients the recellularized lamina into a femtosecond-assisted 9.5-mm diameter lamellar pocket under topical anesthesia. The total duration of follow-up was 6 months. No case showed clinical haze or scarring by month 3. Six months after surgery, patients showed a general improvement of all visual parameters, with a mean unaided visual acuity from 0.109 to 0.232 (P = .05) and corrected distance visual acuity from 0.22 to 0.356 (P = .068). Refractive sphere improved in all patients (from −4.55 diopters [D] to −2.69 D; P = .017), but refractive cylinder remained stable (from −2.83 to −2.61; P = .34). An improvement tendency of all anterior keratometric values was observed. A mean improvement of 120 μm in all thickness parameters was confirmed (P = .008), as well as an improvement in the spherical aberration (P = .018), coma (P = .23) and total higher order aberrations (P = .31). No significant differences among groups were detected. Decellularized human corneal stromal laminas transplantation seems safe and moderately effective for advanced keratoconus. Potential benefits of its recellularization with autologous adipose-derived adult stem cells remains unclear.
Editor: United States: Elsevier Inc
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 3 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Corneal Stroma Enhancement With Decellularized Stromal Laminas With or Without Stem Cell Recellularization for Advanced Keratoconus

Alió del Barrio, Jorge L. ; El Zarif, Mona ; Azaar, Albert ; Makdissy, Nehman ; Khalil, Charbel ; Harb, Walid ; El Achkar, Ibrahim ; Jawad, Ziad Abdul ; de Miguel, María P. ; Alió, Jorge L.

United States: Elsevier Inc

Buscando em bases de dados remotas. Favor aguardar.